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Predictors of non-functional larynx following (chemo)radiotherapy for locally advanced laryngeal cancer
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  • Kristijonas Milinis,
  • Rhydian King,
  • Jeffrey [email protected] ,
  • Rachel Brooker,
  • Rebecca Zammitt,
  • Mark Wilkie,
  • Jason Fleming,
  • Katharine Davies
Kristijonas Milinis
Liverpool University Hospitals NHS Foundation Trust

Corresponding Author:[email protected]

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Rhydian King
Liverpool University Hospitals NHS Foundation Trust
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Liverpool University Hospitals NHS Foundation Trust
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Rachel Brooker
Clatterbridge Cancer Centre NHS Foundation Trust
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Rebecca Zammitt
Clatterbridge Cancer Centre NHS Foundation Trust
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Mark Wilkie
University Hospital Aintree
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Jason Fleming
Liverpool University Hospitals NHS Foundation Trust
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Katharine Davies
Liverpool University Hospitals NHS Foundation Trust
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Abstract

• Non-functional larynx (NFL) was found to affect 30.9 % of patients with locally advanced laryngeal cancer who underwent curative non-surgical laryngeal preservation treatment for stage III/IV disease • The key measures of NFL were long-term gastrostomy and tracheostomy dependence, functional laryngectomy and chronic aspiration. • Multivariate analyses identified current smoking to be associated with 6.8-fold increase in NFL • Patients with pre-treatment hemi-laryngeal fixation were 3.4 times more likely to experience locoregional recurrence.
24 Jul 2022Submitted to Clinical Otolaryngology
11 Aug 2022Submission Checks Completed
11 Aug 2022Assigned to Editor
02 Oct 2022Reviewer(s) Assigned
19 Oct 2022Review(s) Completed, Editorial Evaluation Pending
19 Nov 2022Editorial Decision: Revise Major
13 Dec 20221st Revision Received
20 Dec 2022Submission Checks Completed
20 Dec 2022Assigned to Editor
21 Dec 2022Reviewer(s) Assigned
05 Apr 2023Review(s) Completed, Editorial Evaluation Pending
21 Apr 2023Editorial Decision: Revise Minor
24 Apr 20232nd Revision Received
26 Apr 2023Submission Checks Completed
26 Apr 2023Assigned to Editor
26 Apr 2023Review(s) Completed, Editorial Evaluation Pending
01 May 2023Editorial Decision: Accept