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Gender-based Long-term Outcome for Atrial Fibrillation Patients post Catheter Ablation
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  • Mingjie Lin,
  • Wenqiang Han,
  • Bing Rong,
  • Kai Zhang,
  • Tongshuai Chen,
  • Juntao Wang,
  • Yihan Li,
  • Changli Chen,
  • Lin Wu,
  • Jingquan Zhong
Mingjie Lin
Peking University First Hospital
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Wenqiang Han
Qilu Hospital of Shandong University Department of Cardiology
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Bing Rong
Qilu Hospital of Shandong University Department of Cardiology
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Kai Zhang
Qilu Hospital of Shandong University Department of Cardiology
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Tongshuai Chen
Qilu Hospital of Shandong University Department of Cardiology
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Juntao Wang
Qilu Hospital of Shandong University Department of Cardiology
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Yihan Li
Qilu Hospital of Shandong University Department of Cardiology
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Changli Chen
Qilu Hospital of Shandong University Department of Cardiology
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Lin Wu
Peking University First Hospital
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Jingquan Zhong
Qilu Hospital of Shandong University Department of Cardiology

Corresponding Author:[email protected]

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Abstract

Background Previous research indicates disparities in atrial fibrillation (AF) recurrence and complications following catheter ablation in women; however, long-term outcomes based on gender remain underexplored. Objective This study evaluated the long-term rates of AF recurrence and major adverse cardiovascular and cerebrovascular events (MACCE) following catheter ablation, investigating gender-related risk factors to inform clinical practice improvement. Methods We conducted a retrospective analysis using data from a prospectively observational registry of AF ablation procedures at our institution from 2015 to 2020. Patients were followed up for MACCE and AF recurrence. The risk factors of AF recurrence and MACCE were further explored. Results The study cohort consisted of 2,293 patients, including 1,441 males and 852 females, and had an average follow-up duration of 50.36 months. After catheter ablation, females exhibited a notably higher rate of recurrence compared to males, with a hazard ratio of 1.305 and a 95% confidence interval ranging from 1.101 to 1.547, which was statistically significant (p=0.0014). Gender differences in AF recurrence persisted regardless of early versus late intervention (both p<0.05). No significant difference in MACCE rates was observed between genders. Independent risk factors for AF recurrence included female gender, diabetes, left atrial diameter ≥40 mm. Conclusions Gender differences significantly impact the long-term outcomes of AF recurrence, but not MACCE rates post-catheter ablation. The study highlights the necessity to integrate gender considerations into AF management strategies.
27 Jan 2024Submitted to Journal of Cardiovascular Electrophysiology
28 Jan 2024Submission Checks Completed
28 Jan 2024Assigned to Editor
28 Jan 2024Review(s) Completed, Editorial Evaluation Pending
03 Feb 2024Reviewer(s) Assigned