Background:Angiomatoid fibrous histiocytoma (AFH) is a clinically rare low-grade malignant soft tissue tumor with occasional metastasis,It accounts for 0.3% of all soft tissue tumors, and it occurs most frequently in the extremities, followed by the trunk and head and neck.Primary angiomatoid fibrous histiocytoma of the pulmonary bronchus is rare, In this paper, the clinical and imaging data of a case of Primary angiomatoid fibrous histiocytoma of the pulmonary bronchus are reported and the literature is reviewed. Case description:A 57-year-old female patient developed cough without obvious inducement six months ago, with paroxyspasms of dry cough, chest tightness and shortness of breath, aggravating after activity.Laboratory tests showed:C-reactive protein 50.9mg/L, ferritin 346ng/ml, AFP<0.9ng/ml, CEA 3.45ng/mL,CA199 19.U/mL,CA125 10.50U/mL,CA50 10.60IU/ml,T-SPOT(-).Chest CT scan showed bronchial occlusion, attasis and soft tissue density in the right middle lobe of the lung. Enhanced scan showed uneven enhancement of endobronchial nodules. 18F-FDG PET/CT showed a density shadow of nodular soft tissue in the right lung bronchus. The density was even and the boundary was unclear. The size was about 2.2cm×2.5cm, and the uptake of 18F-FDG was higher than that of uniform uptake, the maximum standard uptake value (SUVmax) was 11.2.Bronchoscopy showed that the mass was nodular or polypoid, nodular, yellow and tough.The results of bronchoscopic biopsy showed:there were histocytes and dendritic cells in the background of lymphocytes and plasma cells, and no components of squamous cell carcinoma.According to the imaging diagnosis, the preoperative diagnosis was inclined to lung cancer. Due to the obvious symptoms of the patient, the family members and the patient requested surgery, and the postoperative pathological diagnosis was Primary angiomatoid fibrous histiocytoma of the pulmonary bronchus. Conclusion:The incidence of primary pulmonary AFH is very low, its clinical manifestations and imaging findings lack characteristics, and the final diagnosis still needs pathology.However, when middle-aged and elderly patients were found to have soft tissue shadows in the bronchus with clear boundaries and uneven density,the enhanced scan was moderately to significantly enhanced,and high FDG uptake on PET/CT scan,AFH should be considered,and surgical resection may be the best treatment.In conclusion, this case report further broadens the spectrum of lung and bronchial tumors.

Background and Purpose: Although the amphiphilic nature of the widely used antithrombotic drug Ticagrelor is well known, it was never considered as a membranotropic agent, which is able to interact with lipid bilayer in a receptor-independent way. In this work we investigate the influence of Ticagrelor on plasma membrane lipid order in platelets and whether this could modulate affinity of P2Y12 receptor to Ticagrelor. Experimental Approach: Here, we combined fluorescent in situ, in vitro and in silico approaches to probe the interactions between the plasma membrane of platelets and Ticagrelor. The influence of Ticagrelor on the lipid order of the platelets’ plasma membrane and large unilamellar vesicles was studied using advanced fluorescent probe NR12S. Further, the properties of the model lipid bilayers in presence of Ticagrelor were characterized by molecular dynamics simulations. Finally, the influence of an increased lipid order on the dose response of platelets to Ticagrelor was studied. Key Results: Ticagrelor incorporates spontaneously into lipid bilayers and affects the lipid order of the membranes of model vesicles and isolated platelets in non-trivial composition and concentration-dependent manner. We showed that higher plasma membrane lipid order in platelets leads to the lower IC50 for Ticagrelor. It is shown that membrane incorporation of Ticagrelor increases the affinity of the drug to its own therapeutic target, the P2Y12 receptor, by means of increasing the order of the platelet’s plasma membrane. Conclusion and Implications: A novel dual mechanism of Ticagrelor action is suggested that combines direct binding to P2Y12 receptor with simultaneous modulation of receptor’s lipid microenvironment.

CASE DESCRIPTION A 5-year-old girl presented to a hospital at night with intermittent vomiting and abdominal pain since the morning. She was exhausted and unable to drink or eat properly but had a normal bowel movement that day. The physician performed abdominal X-ray imaging, which revealed abnormal gas distribution (Fig. 1-a,b). However, her symptoms remained stable. Thus, she was diagnosed with early gastroenteritis, and the physician decided to discharge her. But she was transferred to our hospital the next day with worsening symptoms. She had a history of undergoing surgery for a congenital diaphragmatic hernia at birth. Her physical examination indicated a distended abdomen with periumbilical tenderness on palpation. Furthermore, abdominal X-ray revealed the absence of gas (Fig. 1-c,d), and contrast-enhanced abdominal computed tomography scan revealed an enlarged stomach with rotation and a right-sided spleen (Fig. 2). An indwelling nasogastric tube was successfully inserted under fluoroscopy, and the symptoms of the patient dramatically improved after removing >1 liter of gastric contents. Finally, she was diagnosed with acute gastric volvulus and a wandering spleen.

[Conventional tillage](https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/conventional-tillage) is still widely used in mollisols sloping farmland, which leads to serious [soil erosion](https://www.sciencedirect.com/topics/earth-and-planetary-sciences/soil-erosion) . Effective farming methods have positive significance for alleviating soil erosion .To prevent and control soil and water loss in mollisols sloping farmland,field experiments were carried out in 2022 with three tillage methods and their combination modes(Subsoiling tillage (SF),Ridge tillage and pitting field (RF),Ridge tillage and pitting field + subsoiling tillage (RF-S),Contour tillage (TP),Contour tillage + ridge tillage and pitting field (TP-R),Contour tillage + subsoiling tillage (TP-S)) to evaluate the effects of soil and water conservation under different tillage methods. The results showed that the contour tillage + ridge field treatment significantly reduced surface runoff and soil loss ( P < 0.05), and there was no nutrient loss. Compared with other treatments, this method significantly reduced runoff, erosion, and nutrient loss. The contour tillage + subsoiling tillage treatment significantly reduced the soil three-phase R value and improved the soil texture, and its yield, harvest index, and water use efficiency were higher than those of other treatments. Considered comprehensively, the results show that contour tillage + subsoiling tillage can reduce soil erosion and improve soil quality and water use efficiency while ensuring high production capacity. Furthermore, the results of this study provide a theoretical basis for conserving soil and water resources, improving soil fertility, and increasing farmland yield in the mollisols area of northeast China.

The aim of this study was to investigate the survival, distribution and reaction of different cell types on a monolayer disk, as well as their behavior under bioreactor treatment. Specifically, porcine EEC and porcine fibroblasts (PCF) were labeled with GFT and Texas Red, respectively, to track their viability and distribution. The experiments involved monitoring the cells using various microscopy techniques and comparing the results with controls. These findings have important implications for understanding cell behavior and potential applications for Discrete Subaortic Stenosis. This paper aims to discuss the implications of the findings in the context of existing literature and future research directions.

A document by Marius G. Floriancic. Click on the document to view its contents.

In this paper, we use the generalized notions of Riemann-Liouville (fractional calculus with respect to a regular function σ) to extend the definitions of fractional integration and derivative from the functional sense to the distributional sense. First, we give some properties of fractional integral and derivative for the functions infinitely differentiable with compact support. Then, we define the weak derivative, as well as the integral and derivative of a distribution with compact support, the integral and derivative of a distribution using the convolution product. Then, we generalize those concepts from the unidimensional to the multidimensional case. Finally, we propose the definitions of some usual differential operators.

A devastating complication of Prosthetic Aortic Valve Infective Endocarditis; Aorto-ventricular fistula with periaortic abscess presenting with complete heart blockMohammad Sahebjam1, Mahboobeh Sheikh2*1Associate Professor of Cardiology, Department of Echocardiography, Tehran Heart Center, Cardiovascular diseases Research institute, Tehran University of Medical Sciences, Tehran, IranMail: [email protected]*Assistant professor of Cardiology, Department of Cardiology, Zabol University of Medical sciences, Zabol, IranGmail: [email protected] number: +9891232328041 first author.2*corresponding authorAbstractAortoventricular fistula (AVF) is an uncommon life-threatening condition that can arise after prosthetic valve endocarditis (PVE). In some cases, AVF may be associated with abscess formation, further complicating the condition. We present a case of a 71-year-old man with infective endocarditis of Aortic valve bioprosthesis with aorto-Left Ventricular Outflow Tract ( LVOT) fistula and complete Heart Block ( CHB) following periaortic abscess formation. unfortunately, He passed away before the urgent surgical timeline.Keywords: Infective Endocarditis, Prosthesis, Aortic Valve, Periaortic Abscess, Aorto-ventricular FistulaAortoventricular fistula (AVF) is a rare and lethal complication after prosthetic valve endocarditis (PVE). In PVE, AVF typically develops as a result of the destructive infection that erodes the tissue surrounding the prosthetic valve, leading to the formation of a tract or tunnel connecting the aorta to the adjacent cardiac structure. AVF may be associated with abscess formation. In prosthetic valve endocarditis, abscesses can form in the surrounding tissues, including the myocardium, aortic root, or other nearby structures. And also may destroy the electrical conduction system and lead to Complete Heart Block (CHB). Treatment of AVF includes prompt surgical intervention in addition to Antimicrobial administration.A 71-year-old man presented to the emergency department with complaints of fever, chills, fatigue, night sweat, and dizziness for several days. His medical history was coronary artery bypass graft surgery (CABG) and aortic valve replacement with a TRIFECTA bioprosthesis five months ago.On examination, the patient exhibited fever, bradycardia(HR=30-35 bpm), hypotension (BP=90/50 mmHg), and oxygen saturation of 93%. His electrocardiogram showed sinus rhythm, complete heart block with wide QRS complex (figure 5). Therefore temporary pacemaker was implanted. Laboratory findings showed leukocytosis 18.3×109/l; thrombocytopenia 50×109/l; anemia Hb 8.6/l, Increased ESR and CRP, and negative blood cultures.Three-dimensional Transoesophageal echocardiography revealed multiple mobile vegetations attached to the bioprosthetic aortic valve with significantly increased gradients, severe mixed transvalvular and paravalvular aortic insufficiency, increased thickness of aortic root and intervalvular fibrosa (30mm×16mm) with echo lucent area in favour of periaortic abscess( figure 3) which fistulated into left ventricular outflow tract (LVOT) from one side and Aortic root on the other side. (video 2, figure1-2)This fistulization made a canal-like pathway between LVOT and the aortic root with systolic expansion with turbulent flow from LVOT during systole and expansion with turbulent flow from the aortic root during diastole.(figure 4, video1,3 ) The patient received standard antimicrobial therapy and prepared for prompt reoperation, but his condition deteriorated with progressive multi-organ failure, and passed away before the surgery.DeclarationsEthical ApprovalWritten informed consent was obtained from the patient for publication of this case Imaging.Competing interestsThe authors declare that they have no competing interests associated with this publication.Authors’ contributionMSahebjam was the first author which was the main provider of the data and contributing in writing and editing the manuscript. Msheikh is the corresponding author and contributed in writing and editing the manuscript.FundingThe authors received no financial support for this article’s research, authorship, and publication.Availability of data and materialData are available in a repository and can be accessed using a unique identifier other than a DOI. The data underlying this article are available in the databank of Tehran heart center hospital and can be accessed with the deposition number. However, it must be kept private due to some reasons. First, to protect  the privacy of individual who participated in the study, it is also against the hospital rules and regulations; moreover, the primary language is Persian. Nevertheless, the data will be shared on reasonable request to the corresponding author.Aknowledgement: Not applicableReferencesVideo.1 Transesophageal Echocardiography (TEE) , the X-plane long-axis view of the aortic prosthesis revealing destructive bioprosthetic AV with the prosthesis rocking motion and significant thickening of intervalvular fibrosa (left ). Circumferential periaortic thickness with echo-free spaces, indicative of preaortic abscess formation. (right)Video 2. Transesophageal echocardiography(TEE) long axis view. Bidirectional flow through the fistulous tract with systolic flow toward the Aortic root and diastolic flow toward the Left Ventricular Outflow Tract (LVOT)Video 3. TEE-3D multi Vue

Whilst there are limited data on the environmental impact of administering parasiticide drugs to horses, evidence from other species treated with identical drugs indicates significant negative ecological effects. Anthelmintic drugs may be excreted unchanged or metabolised to other active and/or toxic metabolites that enter the environment through direct excretion during grazing. These chemicals can have significant toxic effects on non-target insects, such as dung beetles, earthworms and aquatic animals. Of the anthelmintics frequently used in horses, ivermectin appears to be the most ecotoxic; available evidence indicates that moxidectin is less toxic. Fenbendazole appears to have little impact on dung-colonising insects but may be toxic to aquatic organisms and fungi. There is very little data regarding the ecotoxicity of pyrantel and praziquantel, although their ecotoxic effects are thought to be low. Pasture hygiene reduces pharmaceutical contamination and also helps to break the endoparasitic cycle of infectivity, thus reducing reliance on anthelmintics. Judicious use of endoparasiticides, along with pasture hygiene measures, will limit the ecotoxic effects of these drugs and reduce the selection pressure that drives anthelmintic resistance. Anthelmintics may also impact the equine gastrointestinal microbiota.Following topical treatment with ectoparasiticides (such as fipronil, permethrin or cypermethrin), there is a risk of contamination of both the immediate environment and water courses. The half-life of fipronil in the environment is variable, but it degrades into compounds which are more toxic; it is highly toxic to bees, and is reported to bioaccumulate in fish and can be toxic to birds. Of the synthetic pyrethroids, permethrin degrades at a faster rate than cypermethrin and may therefore have a lower ecotoxic effect. The ecotoxic effects of injectable doramectin are likely to be similar to oral ivermectin, although persistence in faeces may be significantly prolonged compared to the oral treatment route.

Our goal was to interrogate Janzen’s idea that “mountain passes are higher in the tropics” by investigating putative ecological and biogeographic drivers of patterns of elevational range-sizes among equatorial plant families. We used herbarium records for sixty species-rich plant families, representing a total of 18535 species, to estimate distributions over a 4500 m elevational gradient. For each family, we estimated the change in average range-sizes with increasing elevation (i.e. Rapoport’s rule, abbreviated as ERR) and quantified 15 metrics of familial richness distribution, evolutionary age, and biogeographic affiliation. We visualized covariation across families using used phylogenetic principal components analysis (pPCA), with color illustrating endemism. We then evaluated how family-level ERR slopes correlated with each metric individually, and the first two pPCA components, using phylogenetic independent contrasts. Families with greater Sundaland endemism, or richness that was restricted to tropical lowland forests, had positive ERR slopes. Families with stronger Sahul affiliation, or montane centered richness, had shallower, neutral, or negative ERR slopes. Families with Wallacea affiliation, broader latitudinal or elevational distributions, cosmopolitanism, or older evolutionary age had mixed results. Our findings support Janzen’s hypothesis that “mountain passes are higher in the tropics.” If long term climate stability over millions of years promotes habitat specialization, then among taxa with long-term tropical affiliations, we would expect smaller range-sizes within lowland forests, with range-size expansion towards higher elevations, expressed as a positive ERR slope. Conversely, variation in growing conditions should promote larger, relatively consistent, range-sizes expressed as a neutral ERR slope. Our results support this corollary because of the dichotomy of ERR slopes observed in relation to elevational and historical biogeographic positioning, which may be an indicator of vulnerability of these plant groups to contemporary climate change.

The complex and dynamic interplay between internalization, anterograde transport, recycling and degradation determines the density of functional G protein-coupled receptors (GPCRs) at the cell surface and, consequently, the magnitude of their associated physiological responses. As opposed to most members of the GPCR superfamily, the delta opioid receptor (DOP) is only weakly expressed at the neuronal plasma membrane, thus representing a critical limitation for its use as a therapeutic target. Although DOP appears as a promising candidate for the development of better-tolerated analgesics, the molecular and cellular mechanisms underlying the regulation of its cell surface expression remain poorly characterized. This work investigates the constitutive ( i.e. ligand-independent) trafficking of DOP, an understudied cellular process potentially involved in the control of plasma membrane-localized receptors. In HEK293 cells stably expressing Flag-tagged DOP, we first confirmed that this GPCR is constitutively internalized through a clathrin-dependent and b-arrestin-independent mechanism. Immunofluorescence experiments with selected Rab protein isoforms indicated that internalized DOP was mainly colocalized with the early endosome marker Rab5, as well as the rapid recycling endosome marker Rab4. Co-transfection with Rab5 dominant-negative mutant inhibited the intracellular distribution of the receptor, indicating that its constitutive endocytosis is Rab5-dependent. DOP cell surface expression and ligand-induced signaling were also significantly reduced following Rab4-specific DsiRNA treatments, suggesting a role for this small GTPase in the regulation of DOP constitutive recycling. Mapping of the major region of interaction between DOP and both Rabs revealed that Rab4 binds the third intracellular loop of DOP, whereas Rab5 seems to preferentially interact with the distal region of the C-terminal end of DOP. Altogether, these results show for the first time that DOP constitutive internalization and recycling are critical to maintain its cell surface bioavailability and responsiveness to agonists.

One-hidden-layer feedforward neural networks are described as functions having many real-valued parameters. The larger the number of parameters is, neural networks can approximate various functions (universal approximation property). The essential optimal order of approximation bounds is already derived in 1996. We focused on the numerical experiment that indicates the neural networks whose parameters have stochastic perturbations gain better performance than ordinary neural networks, and explored the approimation property of neural networks with stochastic perturbations. In this paper, we derived the quantitative order of variance of stochastic perturbations to achieve the essential approximation order.

The aim of this paper is to decompose the displacements of thin-walled beams with rectangular cross-section. The decomposition is accompanied by estimates of all its terms with respect to the norm of the strain tensor. Korn's inequality is also given.

Title : Dextrocardia with pulmonary atresia, VSD and ASD, cyanosis reappeared after 12 months of age, Case report.Authors : Alaa Mohammed1, Salam Mohamed11Faculty of medicine and health sciences, International University of Africa, Khartoum, SudanCorresponding author : Dr. Salam Mohamed, MBBS, International University of Africa. Phone: +966535192054, Email: [email protected] , WhatsApp: +249929843164Key Words :Pulmonary atresia, dextrocardiaPulmonary atresia with VSD (ventricular septal defect)Cyanotic heart diseaseDextrocardia with pulmonary atresia, VSD, and ASD (atrial septal defect)Words count : 962 wordsFunding : the authors received no financial support for research, authorship or publishing the article.Conflict of interest : the authors declare there are no conflict of interests

Non-healing cutaneous ulcers: A manifestation of miliary tuberculosis.

Objective: This case report describes the second reported case of ectopic production of beta-hCG in anal cancer Case: 53-year-old female presented with a new anal lesion. Biopsy showed a poorly differentiated squamous cell cancer (SCC) with undifferentiated sarcomatoid features, stage IIIA (cT2cN1cM0). Before starting concurrent chemotherapy and radiation, the patient had

We review some known bounds for eigenvalues of matrices and use similar techniques to derive bounds for nonlinear eigen problems and the eigenvalues for LTI systems with delays as a special case. There are two classes of results. The first are based on Hermitian decompositions, the second on Gershgorin's theorem. The bounds are easily computable. We reflect on implications for stability theory, which may be contrasted with bounds that have been obtained via Riccati stability based on Lyapunov-Krasovskii theory.

Background: Accurate prediction of SARS-CoV-2 severity remains a challenge. Torque Teno Virus (TTV), recognized as a surrogate marker for cellular immunity in solid organ transplant recipients, holds potential for assessing infection outcomes. Objectives: We investigated whether quantifying TTV in nasopharyngeal samples upon emergency ward (ED) admission could serve as an early predictor of SARS-CoV-2 severity. Study design: Retrospective single-center study in the ED of Saint-Louis Hospital in Paris, France. TTV DNA was quantified in nasopharyngeal swab samples collected for SARS-CoV-2 testing. Results: Among 295 SARS-CoV-2 infected patients, 92 returned home, 160 were admitted to medical wards, and 43 to the intensive care unit. Among 295 SARS-CoV-2 patients, 92 were discharged, 160 hospitalized, and 43 admitted to the intensive care unit (ICU). Elevated TTV loads were observed in ICU patients (Median: 3.02 log copies/mL, interquartile range [IQR]: 2.215-3.825), exceeding those in discharged (2.215, [0; 2.962]) or hospitalized patients (2.24, [0; 3.29]) (p=0.006). Multivariate analysis identified diabetes, obesity, hepatitis, fever, dyspnea, oxygen requirement, and TTV load as predictors of ICU admission. A 2.91 log 10 copies/mL TTV threshold independently predicted ICU admission. Conclusion: Nasopharyngeal TTV quantification in SARS-CoV-2 infected patients is linked to the likelihood of ICU admission and might reflect respiratory immunosuppression.