javascript:void(0) In the international photovoltaic market, the "carbon footprint" label has received great attention, and low-carbon footprint products are widely popular. Compared with metallic silver, copper has the characteristics of low carbon emissions and low cost, which can effectively reduce the carbon footprint. Based on this, this article reports a horizontal double-sided Copper metallisation technology. This technology can not only metallize the front and back sides of various types of silicon solar cells at the same time, but also has fast speed, good uniformity, and simple process, making it suitable for the industrial mass production of solar cells. This article describes the structure and manufacturing process of TOPCon solar cells patterned with ultrashort pulse laser and metallized using this novel horizontal double-sided copper metallisation technology. In this batch, average efficiency reached above 26%.

Expanded-Access Use of Elamipretide Improves Quality of Life in Patients with Rare Mitochondrial Disorders Characterized by Ophthalmic Symptoms: A Case SeriesSharique Ansari1, Mary Kay Koenig21. Kane Hall Barry Neurology, 1305 Airport Freeway, Bedford, TX, USA2. University of Texas McGovern Medical School, Department of Pediatrics, Division of Child & Adolescent Neurology, Center for the Treatment of Pediatric Neurodegenerative Disease, Houston, TX, USACorresponding Author : Mary Kay Koenig, MD, [email protected]: Sharique Ansari, [email protected]: The authors wish to thank the patients and their families for participating, as well as Jamie Dermatis, DPM, and Jim Shiffer, RPh, Write On Time Medical Communications, LLC, for their writing and editorial assistance during the development of this manuscript. Mary Kay Koenig wishes to thank her research nurse, Lindsey Miller, for providing patient support and assisting with administration and education responsibilities.Conflict of Interest Statement: The authors have no conflicts of interest to declare.Data Availability: The data that support the findings of this case report are not publicly available due to the data containing information that could compromise the privacy of the patient, but may be available from the corresponding author upon reasonable request.Ethics Approval Statement: FDA and local IRB review and approval were obtained prior to initiating therapy with elamipretide subcutaneously daily under this EAP.Patient Consent Statement: Written informed consent was obtained from the patients to be included in this study.Funding: Stealth BioTherapeutics provided support in supplying elamipretide for the patients and publishing this case series. The authors confirm independence from the sponsor. The content of the article has not been influenced by the sponsor.Keywords: Elamipretide, Mitochondrial Disease, Cardiolipin, NARP syndrome, CPEOKey Clinical Message: This case series presents the use of elamipretide in two patients with different progressive mitochondrial disorders (chronic progressive external ophthalmoplegia [CPEO] plus and neuropathy, ataxia, and retinitis pigmentosa [NARP] syndrome) characterized by ophthalmic traits. Elamipretide was well tolerated and both patients demonstrated improvement in symptoms while on therapy.

Acute lymphoblastic leukemia (ALL) is a rare cause of hypereosinophilia (HE). We present a case of B-ALL and HE-associated lung inflammation to shed light on the diagnostic challenges in this rare entity. Bone marrow examination in the context of persistent HE is crucial, even in the absence of other cellular morphological abnormalities in the peripheral blood. This form of ALL is associated with severe complications and inferior outcome due to HE-induced organ damage, therefore a quick initiation of therapy is essential. Furthermore, reports of higher incidence of thromboembolic complications merit careful monitoring during therapy and evaluation of prophylactic measures.

javascript:void(0) Antioxidants are known for their health beneficial effects by reducing oxidative damage, increasing free radical scavenging rate, blocking and terminating oxidation reactions. They have been widely used as supplements in food, cosmetics, nutraceuticals and medicines. Emerging researches increasingly indicate that the development of diverse research methodologies and the exploration of new microorganisms for heterogeneous synthesis of antioxidants play an indispensable role in socioeconomic development. In this study, we engineered Saccharomyces boulardii for probiotic supplementation of antioxidants such as L-ergothioneine (EGT). We first constructed double knockout of ura3 and trp1 gene in S. boulardii, to facilitate plasmid-based expressions. To further enable effective genome editing of S. boulardii, we implemented the PiggyBac system to transpose the heterologous gene expression cassettes into the chromosomes of S. boulardii. By using enhanced green fluorescent protein (EGFP) as the reporter gene, we achieved random chromosomal integration of EGFP expression cassette. EGT-producing strains were subsequently obtained via the PiggyBac transposon system. One isolated S. boulardii mutant produced EGT at 17.50 mg/L after 120 h cultivation. In summary, we have applied the PiggyBac transposon system to S. boulardii for the first time for genetic engineering. The engineered probiotic yeast S. boulardii has been endowed with new antioxidant properties and produces EGT. It has potential applications in developing novel therapeutics and dietary supplements for the prevention and treatment of gastrointestinal disorders.

From Dyspnea to Diagnosis: A Pediatric Case Report on an Unexpected ConditionYotam Ophir, MD1, Marketa Bloomfield, MD, PhD2, Jana Tukova, MD, PhD1Department of Pediatric and Inherited Metabolic disorders, General University Hospital, First Faculty of Medicine, Charles University, Prague, Czech Republic.2 Department of Immunology, Motol University Hospital, 2nd Faculty of Medicine, Charles University, Prague, Czech Republic.

javascript:void(0) Tumor patients take a high risk of SARS-CoV-2 infection, high incidence of serious events, poor prognosis and high mortality in the coronavirus disease 2019 (COVID-19) epidemic, but there is still lack of supporting evidence that the COVID-19 vaccination is beneficial for tumor patients to encourage them to receive the vaccination. A cross-sectional study was conducted in Shantou, China and questionnaires were collected in the hospitals from February 13,2023 to April 23,2023. Using the receiving of COVID-19 vaccination as the primary outcome, descriptive, univariate and multivariate analyses were generated.161 out of 241 patients (66.80%) had received at least one dose of COVID-19 vaccine and 61.00% patients had been infected with SARS-CoV-2. Patients with general symptoms (P = 0.013) and others (P = 0.022) had a higher proportion of non-vaccinated patients than vaccinated ones. In the multivariate analysis, age (aOR = 0.971, 95% CI 0.946-0.997, P = 0.031), the cognition of vaccines’ impact on tumor treatment (aOR = 4.475, 95% CI 1.772-11.299, P = 0.002), time since tumor diagnosis (aOR=4.586, 95% CI 2.122-9.909, P < 0.001) were identified as factors of COVID-19 vaccination uptake. COVID-19 vaccination in China brings many benefits to tumor patients, which could reduce symptoms after infection.

Background: Periostin mediates inflammation and fibrosis by regulating ECM adhesion, migration, and differentiation in multiple organ diseases. Studies have shown Periostin mainly located in the dilated mesangium, tubulointerstitial and fibrotic regions of the diabetic nephropathy, which is negatively correlated with renal function. However, the underlying mechanisms remain poorly explored. Methods: The expression of periostin in HK-2 cells was investigated under high glucose and high concentration of TGF-β1. The signaling pathway of periostin involved in epithelial-mesenchymal transdifferentiation of HK-2 cells was also validated. The expression of periostin were investigated by RT-PCR with different concentration of glucose and TGF-β1. Periostin expression in HK-2 cells stimulated by high glucose and high TGF-β1 was detected by western blotting and immunofluorescence. The expression of E-Cad, α-SMA and p38 proteins were also detected. The effects of p38 inhibitors on periostin, E-Cad and α-SMA in high glucose environment were also investigated and verified. Results: High concentration of glucose and TGF-β1 increased the fibrosis of HK-2 cells, prompting high expression of periostin. The combined stimulation of high glucose (22 mmol/L) and high TGF-β1(10 ng/mL) upregulated the expression of periostin obviously, stimulating the expression of α-SMA and p38 while inhibiting the secretion of E-Cad. More importantly, p38 inhibitors reduced the expression of periostin and α-SMA protein while promoted E-Cad protein expression in HK-2 cells under high glucose conditions. Furthermore, p38-MAPK signal pathway was involved in the epithelial-mesenchymal transition of human renal tubules in high glucose environment. Conclusion: Periostin, a downstream factor of TGF-β1, is positively regulated by TGF-β1 under high glucose condition, affecting the epithelial-interstitial differentiation of HK-2 cells via the p38-MAPK signaling pathway. Therefore, periostin may serve as a biomarker of renal fibrosis in diabetic kidney disease.

A Protocol for Treating Atelectasis in the Chronically Ventilated Pediatric PatientEliezer Be’eri MBBCh, Nitay Fraenkel MD, Orit Bartov BSc. MPt. Ped, Noah Eisenberg BPT, Rachelle Lavi B Physio, Ofra Ginat BPT, Ma’ayan Shoffer BPT.Department of Respiratory RehabilitationAlyn Pediatric Rehabilitation HospitalJerusalem, IsraelPresented at the 2nd meeting of the International Society of Pediatric Respiratory Diseases (INSPiRED), 2024.ORCID ID (Eliezer Be’eri): 0000-0003-4935-6000Email addresses of authors:Eliezer Be’eri: [email protected] Fraenkel: [email protected] Bartov: [email protected] Lavi: [email protected] Eisenberg: [email protected] Ginat: [email protected]’ayan Shoffer: [email protected] should be addressed to:Eliezer Be’eri, MDALYN Hospital84 Shmaryahu Levin Street, Jerusalem, Israel 91090Phone: +972 [email protected] words: Atelectasis, physiotherapy, tracheostomy, mechanical ventilationAbbreviated title: Protocol for treating atelectasisTo the editor,Lung atelectasis is an important complication occurring in children and adolescents who are ventilator-dependent due to neuromuscular respiratory failure. It may occur if a “low tidal volume” ventilation strategy is used, as is commonly done to avoid barotrauma when ventilating subjects with parenchymal respiratory failure. However, the patient in respiratory failure due to neuromuscular disease, in contrast to the subject with parenchymal respiratory failure, is primarily at risk for alveolar de-recruitment, rather than barotrauma. Some authorities have therefore advocated using a “high tidal volume strategy” \RL1. In the short term, atelectasis causes ventilation-perfusion mismatch, but if left untreated it may become a focus of recurrent infection and eventual bronchiectasis. When atelectasis is identified, it is therefore essential to re-recruit the atelectatic lung segment as early as possible, prior to the atelectasis becoming permanent.A standardized protocol for treating newly diagnosed atelectasis in ventilator-dependent children has been developed and implemented in the Respiratory Rehabilitation Department of Alyn Pediatric Rehabilitation Hospital in Jerusalem, Israel. The protocol aims to achieve rational medical and physiotherapy (PT) resource management in a stepwise and time-limited manner. The protocol employs the full spectrum of medical and physiotherapy modalities available at Alyn Hospital, including alveolar recruitment by means of prolonged “sigh” inhalations, mechanical inexsufflation (MIE), intrapulmonary percussive ventilation (IPPV), Vest therapy, negative-pressure cuirass ventilation (RTX), “green-bag” manual hyperinflation and bronchoscopy, and is detailed in diagram 1.The initial step is to maximize the ventilator parameters (peak inspiratory pressure (PIP) or tidal volume (Vti), and peak end expiratory pressure (PEEP)) and add a sigh recruitment manoeuvre of 40 cmH2O for 10 seconds every 20 minutes. In our experience, addition of the sigh recruitment maneuver often succeeds in opening the atelectatic segment, and no further therapy is needed. After 24 hours a chest Xray is performed. If no clinical (oxygen saturation above 94% or return to pre-atelectasis baseline) or radiological improvement has occurred, physiotherapy treatments are then added in a stepwise manner every 48 hours. Our initial physiotherapy protocol comprises manual chest vibration and ventilation-enhancement maneuvers combined with patient positioning to enhance postural drainage. Such positioning may be prone, or lying on the side with the atelectatic lung superior, and may include use of an abdominal belt to improve diaphragmatic function. Manual physiotherapy is combined with MIE and either IPPV (for tracheostomized subjects) or Vest therapies (if the subject is using non-invasive positive-pressure ventilation (NIPPV)), all performed three times a day. Whereas the Vest and IPPV achieve secretion mobilization (essentially, shaking secretions free of the tracheo-bronchial wall), MIE performs secretion removal (moving the secretions up the airways towards the pharynx). The protocol aims to combine mobilization and removal modalities synergistically. If no clinical improvement has occurred after 48 hours, the physiotherapy modality is changed to use of a negative-pressure cuirass (RTX) in secretion removal mode. Our rationale in choosing this technique is that during negative-pressure ventilation, chest wall expansion occurs in a manner that is morphologically different from the manner in which the thorax expands during positive-pressure ventilation, reflecting the difference between “inflating” the lungs from within versus expanding the chest wall from without. We postulate that this morphological difference manifests also at the level of the airways, meaning that there may be differences between positive-pressure and negative-pressure ventilation in terms of how airways physically expand when exposed to these two modalities. If that is in fact true, negative-pressure ventilation may succeed in achieving alveolar recruitment when positive-pressure ventilation has failed to do so. Indeed, in our experience we have witnessed successful recruitment of an atelectatic segment within 24 hours of initiating negative-pressure ventilation, in cases in which the initial positive-pressure ventilation combined with secretion-mobilization methodologies for 72 hours had failed to achieve such. In particularly resistant cases we have also combined RTX ventilation with simultaneous and synchronous positive-pressure ventilation.In children younger than 2 years of age it may be difficult to successfully fit a negative-pressure cuirass to a small thorax, which precludes using that therapy as a next step after failure of first-line PT techniques. In such circumstances, we employ a technique for achieving prolonged lung insufflation using an anesthesiology “green bag” manual resuscitator. In this technique, a slow, prolonged inspiration with a sustained inspiratory pause is followed by rapid release during the expiratory phase. As small children generally still have a pliable chest wall, this technique can often be effective in achieving sustained and high PEEP levels, encouraging alveolar recruitment.We reserve bronchoscopy for those cases in which no ongoing improvement has been achieved after one week of recruitment-enhancing therapies. This is due to a combination of the invasiveness of the procedure with the low likelihood (in our experience) that bronchoscopy alone will achieve re-expansion of an atelectatic lung segment (unless such atelectasis has been caused by a solid, aspirated foreign body that can be removed).In summary, the described protocol is a pathway for opening a newly diagnosed atelectasis in a chronically ventilated child, in a manner that maximizes the number of potentially beneficial treatment modalities employed in a time-limited and rational framework.Abbreviations:PT: physiotherapyMIE: mechanical inexsufflationIPPV: intrapulmonary percussive ventilationNIPPV: non-invasive positive-pressure ventilationRTX: negative-pressure cuirass ventilationPIP: peak inspiratory pressureVti: inspired tidal volumePEEP: peak end expiratory pressure

Carbon stock options to mitigate climate change have become a major area of interest across the globe. Climate change is a global issue, and every possible way to mitigate it, is being explored. Afforestation and ecosystem restoration activities are widely adopted to improve the potential of the land in carbon storage. The Kerala State Action Plan on Climate Change proposed the ‘Trees outside forests (Tof)’ as an effective mechanism to mitigate climate change. Due to its discrete distribution and non-uniformity, there are fewer attempts to measure the potential of these systems. This study tried to determine and compare the carbon (C) stock potential of the three “Trees outside forest (Tof)” conditions prevailing in the Palakkad district, Kerala. The carbon stock by standing biomass and soil of four sites of undisturbed natural vegetation, monoculture plantation, and home garden was estimated using allometric equations and computations. The natural vegetations was found to have a higher carbon stock potential (238.58 Mg ha -1) compared to monoculture plantation and human habitat. Also, natural vegetation’s soil organic carbon content was much higher than monoculture plantations and home gardens. The study also estimated the soil deterioration index of each land use compared to the natural vegetation and barren land. The results of the study suggested that land use has a great influence on soil quality and carbon stock potential. Proper management of these Tof systems can enhance their productivity and contribute accountable support towards mitigating climate change.

Many cellular processes and organismal behaviors are time-dependent, and asynchrony of these phenomena can facilitate speciation through prezygotic and postzygotic reinforcement mechanisms. The Mojave and Sonoran desert tortoises (Gopherus agassizii and G. morafkai, respectively) reside in adjoining deserts with distinct seasonal rainfall patterns and they exhibit asynchronous winter brumation and reproductive behaviors. We used whole genome sequencing of 21 individuals from the two tortoise species and an outgroup to understand genes potentially underlying these characteristics. Eighty percent (80%) of the mutations in the most diverged 1% of the genome (FST ≥ 0.63) mapped to putatively non-functional flanking regions. Diverged genes with putatively functional variation showed extensive mutations in regulatory elements, particularly in predicted promoter regions. Clusters of genes relating to UV nucleotide excision repair, mitonuclear, and homeostasis functions had mutations in these diverged regions. Genes mediating chronobiological (cell cycle, circadian, and circannual) processes were also among the most highly diverged regions (e.g., XPA and ZFHX3). Promoter mutations had significant enrichment of genes related to regulatory machinery (ARC-Mediator complex, HDACs) suggest transcriptional cascades driven by regulatory divergence may underlie the behavioral differences between these species, leading to asynchrony-based prezygotic isolation. Further investigation revealed extensive expansion of respiratory and intestinal mucins (MUC5B, MUC5AC) within Gopherus, particularly G. morafkai. This expansion could contribute to differential Mycoplasma agassizii infection rates between the two species, as mucins help clear bacterial infections. Overall, results highlight that evolution of transcription regulation, apart from protein changes, might play an important role in the divergence and reinforcement during speciation.

In fishes, maternal size typically influences the number of offspring. Although this size-fecundity relationship often varies among species and is considered to be a consequence of the coevolution of life-history traits, the genetic basis of such size-fecundity relationships remains unclear. We explored the genetic basis underlying this size-fecundity relationship in two small medaka species, Oryzias latipes and O. sakaizumii. Our findings showed that O. sakaizumii has a higher fecundity than O. latipes, and quantitative trait locus analysis using interspecific F2 hybrids showed that chromosome 23 is linked to the size-fecundity relationship. In particular, the genes igf1 and lep-b in this region are known to be associated with life-history traits. Because O. sakaizumii is distributed at higher latitudes and has a shorter spawning season than O. latipes in the wild, we propose that adaptation to high latitudes is responsible for the relatively high fecundity observed in O. sakaizumii. We also discuss the potential ecological ramifications by the evolution of increased fecundity in this species.

Two Common Diagnostic Challenges of Juvenile Myelomonocytic LeukemiaJinjun Cheng MD PhD1,3,4*, Sarah Harney MD1, 2, David Jacobsohn MD1, 2, Reuven Schore MD1,2*Center for Cancer and Blood Disorders, Children’s National Hospital, Washington, DCDepartment of Pediatrics, The George Washington University School of Medicine and Health Sciences, Washington, District of Columbia, USADivision of Pathology and Laboratory Medicine, Children’s National Hospital, Washington, DCDepartments of Pathology and Pediatrics, The George WashingtonUniversity School of Medicine and Health Sciences, Washington, District of Columbia, USA

Navigating the Needles: Unveiling the Risks of Acupuncture, A Case ReportHarkesh Arora1, Dhiran Sivasubramanian2, Sinduja Sivakumar 3, Sivaguha Yadunath4, Sreekanth Avula5(corresponding author)1Lovelace Medical Center, 601 Dr. Martin Luther King Jr Ave NE, Albuquerque, NM USA 871022Christian Medical College and Hospital Vellore3Burrell College of Osteopathic Medicine4Mercy Catholic Medical Center - Mercy Fitzgerald Campus5University of Minnesota, Twin Cities, PWB, 516 Delaware St SE 6-207, Minneapolis, MN, USA 55455; [email protected]

Mesenchymal stem cells (MSCs) derived exosomes, as a cell-free therapy to replace MSCs, have higher safety and great potential in regenerative medicine. The isolation of exosomes is a challenge that complicates their application. The commonly used ultracentrifugation and tangential flow filtration methods are inconvenient due to the need for expensive instruments and ultrafilter membranes. The cost of commercial kits limits their application in handling large samples. PEG precipitation is convenient and cost-effective. However, there is a need for optimized and standardized isolation methods based on PEG precipitation in different cell types or liquids to ensure consistent quality and yield. In this work, we optimized the PEG precipitation method for exosomes isolation and compared its effectiveness to two commonly used methods: ultracentrifugation (UC) and commercial exosome isolation kits (ExoQuick). The recovery rate of the optimized PEG method ( about 61.74%) was comparable to that of the commercial ExoQuick kit (about 62.19%), which was significantly higher than UC (about 45.80%). Exosome cargo analysis validated no significant differences in miRNA and protein profiles associated with the proliferation and migration of exosomes isolated by UC and PEG precipitation, which was confirmed by gap closure and CCK8 assays. These findings suggest that PEG-based exosomes isolation could be a highly efficient and high-quality method and may facilitate the development of exosome-based therapies for regenerative medicine.

Wheeze is the musical continuous sound produced by oscillations in any critically narrowed airways, and heard mostly on expiration. It is common in preschool age, about half of all children will experience an episode of wheezing by their sixth birthday. Asthma is usually characterized by cough, wheeze, chest tightness and fast breathing. It is a significant global health issue and affects both children and adults. The prevalence is on the increase, especially in LMIC. Studies from different populations have revealed the key role influencing the progression from preschool wheezing to childhood asthma. Recurrent wheezing is four or more episodes in the preceding year and has a spectrum of phenotypes and with heterogeneous features. Phenotypes of wheezing were proposed to facilitate the identification of young children who are at risk of subsequent development of asthma. The epidemiology and environmental determinants of recurrent wheezing and asthma are discussed.

not-yet-known not-yet-known not-yet-known unknown Pneumonia is an infection affecting the lower airway, where the air sacs are filled with mucus and pus; and typically presents with cough, fever, and fast breathing. Pneumonia is estimated to be the leading cause of mortality in children under five worldwide with 120 million episodes result in one million deaths globally. 1 The Low-Income and Middle-Income Countries (LMICs) are more affected. In a study in southeast Nigeria, 2 bronchopneumonia accounted for 41.9%, of the cases admitted in the tertiary hospitals and in another hospital based study among children, 3 pneumonia had the highest respiratory admission rates at 34.0%. Pneumonia can be caused by various organisms: Bacterial (Streptococcus, staphylococcus etc), Viral (RSV) and recently COVID 19 pneumonia. RSV has been noted globally to be a major cause of childhood lower respiratory tract infection, with morbidity/mortality occurring in 99% of (LMICs). 4 Some of the long term sequalae are discussed

Abstract: Background: The transesophageal echocardiogram (TEE) is the standard imaging modality for confirming the presence or absence of patent foramen ovale. There is a causal association between PFO and unexplained stroke. It seems that 3D-TEE can present a high-risk PFO morphological feature, which seems to show more than just being easier to open. Methods: In total 134 consecutive patients with cryptogenic stroke or migraine who had suspected PFO and underwent c-TCD, TTE, and c-TEE were included in this study. TEE confirmed the PFO. The right-to-left shunt (RLS) grade of PFO at rest and abdominal compression Valsalva maneuver was detected by c-TEE. Results: The long diameter of FO (1.74±0.3 vs. 1.60±0.4, P=0.039), the short diameter of FO (1.12±0.3 vs. 1.00±0.3, P=0.036), perimeter of FO (4.62±0.7 vs. 4.22±1.0, P=0.026) and area (1.80±0.8 vs. 1.35±0.8, P=0.05) of the FO were significantly larger in the larger RLS group. The cut-off value calculated by ROC for the diagnosis of high-risk PFO was that the length of the PFO tunnel was 12 mm and Left funnelform combined with multiple exits of left atrial (sensitivity was 92%, specificity was 90%). Conclusions: A larger oval fossa can be more easily activated and cause a large right-to-left shunt. The left funnelform, a longer length of the PFO tunnel, and multiple exits of the tunnel of LA increase the risk of CS in anatomical of PFO respect. TEE can precisely visualize the specific morphological characteristics of PFO. These features on TEE have a strong correlation with CS.

Over the past decade, the extensive consumption of finite energy resources has caused severe environmental pollution. Meanwhile, the promotion of renewable energy sources is limited by their intermittent and regional nature. Thus, developing effective energy storage and conversion technologies and devices holds considerable importance. Zinc-ion hybrid supercapacitors (ZISCs) merge the beneficial aspects of both supercapacitors and batteries, rendering them an exceptionally promising energy storage method. As an important cathode material for ZISCs, the tunnel structure MnO 2 has poor conductivity and structural stability. Herein, the Zn xMnO 2/PPy (ZMOP) electrode materials are prepared by hydrothermal method. Doping with Zn 2+ is used to enhance its structural stability, while adding polypyrrole to improve its conductivity. Therefore, the fabricated ZMOP cathode presents superb specific capacity (0.1 A g -1, 156.4 mAh g -1) and remarkable cycle performance (82.6%, 5000 cycles, 0.2 A g -1). Furthermore, the assembled aqueous ZISCs with ZMOP cathode and PPy-derived porous carbon nanotubes anode obtain a superb capacity of 109 F g -1 at 0.1 A g -1. Meanwhile, at a power density of 867 W kg -1, the corresponding energy density can achieve 20 Wh kg -1. And over 5000 cycles at 0.2 A g -1, the ZISCs can exhibit excellent cycle stability (86.4%). This suggests that ZMOP nanowires are potential cathode materials for superior-performance aqueous ZISCs.