Email spam, characterized by unsolicited and often harmful messages, remains a pervasive issue across digital communication platforms. This study explores advanced Machine Learning (ML) and Deep Learning (DL) methodologies to enhance email spam detection, aiming to protect users from phishing, malware, and other malicious threats. A comprehensive literature review is conducted, detailing the processes involved in developing spam detection models, including preprocessing, feature extraction, and model implementation. This study focuses on three ML algorithms-Random Forest (RF), Naive Bayes (NB), and Support Vector Machine (SVM)-and three DL models-Long Short-Term Memory (LSTM), Bidirectional Long Short-Term Memory (Bi-LSTM), and Bidirectional Encoder Representations from Transformers (BERT). A comparative analysis of these models is presented, highlighting their accuracy and performance. Notably, DL models, particularly BERT, achieved the highest accuracy (up to 99.14%), while ML models like SVM also demonstrated strong performance (up to 99.00%). The findings indicate that DL models outperform traditional ML algorithms in accuracy, although ML models offer advantages in interpretability and computational efficiency. This study concludes with insights into the strengths and weaknesses of both approaches and suggests future research directions to enhance the robustness and effectiveness of spam detection systems.