The Global Change Information System (GCIS), a product of the U.S. Global Change Research Program (USGCRP), is an open-source, web-based resource designed for use by scientists, decision-makers, and the public. As a centralized catalog of all materials and data used for USGCRP products and climate assessments, the system acts as an advanced, multifaceted bibliography, maintaining traceable provenance records of scientific information and providing access to the original data and research. The GCIS documents the cross-links among research papers, researchers, original data, and more and includes links back to authoritative sources for its information. In addition, the GCIS guides users to global change research produced by the 15 USGCRP federal member agencies.To ensure that the data and metadata in GCIS is findable and accessible, and to maintain the accessibility, citation, data integration, and provenance of the resources within the system, GCIS utilizes external persistent identifiers such as DOIs, ORCIDs, RORs, ISBNs, and ISSNs. Persistent Identifiers in GCIS emphasize and adhere to FAIR principles by ensuring that the data models incorporate these IDs with stable links, standardized resolutions, formats and citations. This presentation will discuss the use cases of persistent identifiers in GCIS, the long-term benefits, integrity, and sustainability of GCIS data models or resources using PIDs, and the efforts undertaken to incorporate PIDs over time as GCIS evolves.