Essential Site Maintenance: Authorea-powered sites will be updated circa 15:00-17:00 Eastern on Tuesday 5 November.
There should be no interruption to normal services, but please contact us at [email protected] in case you face any issues.

loading page

N-terminal Pro-brain Natriuretic Peptide plasma levels are Associated With a Short-Term Diagnosis of Cancer in Patients with Coronary Artery Disease
  • +17
  • Jose Tuñon,
  • Alvaro Aceña,
  • Ana Pello,
  • Sergio Ramos-Cillan,
  • Juan Martínez Milla,
  • Oscar Gonzalez-Lorenzo,
  • Jesus Fuentes-Antras,
  • Nieves Tarin,
  • Carmen Cristobal,
  • Luis M. Blanco-Colío,
  • Jose Luis Martin-Ventura,
  • Ana Huelmos,
  • Carlos Gutierrez-Landaluce,
  • Joaquin Alonso,
  • Lorenzo Lopez-Bescós,
  • Marta Lopez-Castillo,
  • Luis Alonso-Pulpón,
  • Jesus Egido,
  • Ignacio Mahillo-Fernandez,
  • Oscar Lorenzo
Jose Tuñon
Hospital Universitario Fundacion Jimenez Diaz

Corresponding Author:[email protected]

Author Profile
Alvaro Aceña
Hospital Universitario Fundacion Jimenez Diaz
Author Profile
Ana Pello
Hospital Universitario Fundacion Jimenez Diaz
Author Profile
Sergio Ramos-Cillan
Universidad Autonoma de Madrid
Author Profile
Juan Martínez Milla
Hospital Universitario Fundacion Jimenez Diaz
Author Profile
Oscar Gonzalez-Lorenzo
Hospital Universitario Fundacion Jimenez Diaz
Author Profile
Jesus Fuentes-Antras
Hospital Clinico Universitario San Carlos
Author Profile
Nieves Tarin
Hospital Universitario de Mostoles
Author Profile
Carmen Cristobal
Hospital Universitario de Fuenlabrada
Author Profile
Luis M. Blanco-Colío
Hospital Universitario Fundacion Jimenez Diaz
Author Profile
Jose Luis Martin-Ventura
Universidad Autonoma de Madrid
Author Profile
Ana Huelmos
Hospital Universitario Fundacion Alcorcon
Author Profile
Carlos Gutierrez-Landaluce
Hospital Universitario de Fuenlabrada
Author Profile
Joaquin Alonso
Hospital Universitario de Getafe
Author Profile
Lorenzo Lopez-Bescós
Universidad Rey Juan Carlos
Author Profile
Marta Lopez-Castillo
Hospital Universitario Fundacion Jimenez Diaz
Author Profile
Luis Alonso-Pulpón
Hospital Universitario Puerta de Hierro Majadahonda
Author Profile
Jesus Egido
Fundacion Jimenez Diaz Hospital
Author Profile
Ignacio Mahillo-Fernandez
Hospital Universitario Fundacion Jimenez Diaz
Author Profile
Oscar Lorenzo
Universidad Autonoma de Madrid
Author Profile

Abstract

Background NT-proBNP plasma levels may predict a future cancer diagnosis(CD)in patients with coronary artery disease(CAD).In this paper we test whether this could merely represent the detection of increased NT-proBNP levels in subclinical tumors. Methods We studied 962 patients with stable CAD and free of cancer and heart failure at baseline. NT-proBNP, galectin-3, monocyte chemoattractant protein-1,high-sensitivity C-reactive protein, high-sensitivity cardiac troponin I(hsTnI),and calcidiol plasma levels were assessed.The primary outcome was new CD. Results After 5.40(2.81-6.94)years of follow-up,59 patients received a CD.We divided the population in three subgroups: those not developing cancer during follow-up (group A;N=903),and those receiving a CD in the first 3 years of follow up(group B; N=30),or later (group C;N=29).At baseline, 3.3% of patients of group B,0.0% in groups C and 12.3% in group A(p=0.036) presented a previous history of heart failure.In group B,NT-proBNP[HR1.036 CI(1.015-1.056)per increase in 100 pg/ml;p=0.001],previous atrial fibrillation[HR3.140 CI(1.196-8.243);p=0.020],and previous heart failure[HR0.067 CI(0.006-0.802);p=0.033]were independent predictors of CD at multivariate analysis.In group C there were not significant predictors of CD. Conclusions In patients with CAD,NT-proBNP is an independent predictor of CD in the first three years of follow-up,but not later,suggesting that it could be detecting subclinical undiagnosed cancers.New studies in large populations are needed to confirm these findings. What is already known about this topic? It has been linked in previous studies that NT-Pro-BNP elevation could be related to future diagnosis of some cancers especially renal tumors. It has also seen that NT-ProBNP is related to mortality in cancer patients.Finally, our group has previously seen that NT-Pro-BNP predicts cancer diagnosis in patients with myocardial infarction. What does this article add? According to our previous investigations this study support the idea that NT-Pro-BNP is a good marker for further cancer diagnosis not only in patients with myocardial infarction but across the spectrum of the whole CAD