We report a 54-year-old man with treatment-resistant depression (TRD) and hypothyroidism who responded to LT3/LT4 combination, rather than LT4 alone. He was able to discontinue all antidepressant medications eventually. Interestingly, the patient has a DIO2 polymorphism.

We described an atypical presentation of papillary thyroid cancer metastasized to left finger. This case highlights the importance of an early and effective engagement of multidisciplinary team approach with family in order to optimize patient care.

Described is an atypical presentation of a rare condition. It highlights the importance of thorough algorithm of medical and family history, physical examination, appropriate investigations and perioperative workup and for surgery. This case raises the awareness that a lateral neck mass (or lateral ectopic thyroid mass) can be benign.

Adrenocortical carcinoma (ACC) is one of the causes for large retroperitoneal masses. Symptoms could be minimal if the tumor is not hormonally active. We describe a case with only dull flank pain as an initial presentation. Imaging studies confirmed a large, irregular mass with central necrosis and calcification.

This is an atypical presentation of a rare diagnosis. It emphasizes the need for thorough medical history, family history, physical examination and workup. It also demonstrates how even nonfunctional paragangliomas can cause mass effect leading to symptoms.

Cervical lymphadenopathy is a very common complaint for patients presenting to an endocrinology clinic. This case highlights common locations that malignancy presents at as well as their ultrasound characteristics.

We present an adult patient with Crouzon syndrome manifesting with facial deformities and panhypopituitarism. Crouzon syndrome is a rare, autosomal dominant genetic disorder characterized by facial bone deformities, such as a prominent nose, frontal bossing, and ocular proptosis, as well as headaches, seizures, and developmental delay.

Thyroid nodules are often incidentally noted on imaging studies with an estimated incidence of 25% on neck CT scan. The presence of a PET-avid thyroid nodule, especially in a patient with a history of malignancy, should prompt evaluation with fine-needle aspiration to evaluate for malignancy given the high probability.

This case highlights the anterior neck as an unusual location for a lipoma. It is often mistaken for a thyroid nodule as they typically are located on the posterior or lateral neck. It also emphasizes the accuracy of fine need aspiration (FNA) in diagnosing lipomatous tumors.