Background: In Italy both the consumption of antibiotics and the prevalence of bacterial resistance are higher than in other European countries. In 2017, the first National Action Plan on Antimicrobial Resistance (PNCAR) was adopted in Italy. In response to the PNCAR two National Reports on Antibiotics’ use in the human setting have been published. The article’s aim is to describe the pattern of antibiotics consumption in the community setting in Italy from 2013 to 2018. Methods: In order to analyse the consumption for reimbursed antibiotics dispensed by community pharmacies different data sources were used. Consumption was measured in terms of Defined Daily Dose (DDD), prescriptions or prevalence of use. Results: In 2018, the consumption of antibiotics in Italy amounted to 16.1 DDD per 1,000 inhabitants per day. The rates of consumption by geographical area were: 12.7 DDD in the North, 16.9 in the Centre and 20.4 in the South. The use was greater in the extreme age groups than in the population aged from 20 to 64 years. The consumption was higher in winter season with high peaks in the incidence of flu syndromes. In the paediatric population, a utilization rate of 1,010 prescriptions per 1,000 children, with a prevalence of use of 40.8%, was found. Conclusion: The study provides useful information on geographical variability of antibiotics’ use in Italy to guide decision makers in the introduction of tailored interventions, as suggested by PNCAR, aimed at promoting a more rational use of antibiotics for humans and reducing antimicrobial resistance.