Background: Increased risk of thromboembolism during COVID-19 disease is confirmed. Case: A 40-year-old hypertensive otherwise healthy male with COVID-19 disease, presented with exacerbating dyspnea, demonstrated two large mural thrombus in right atrial appendage and right ventricular apex accompanied by pulmonary thromboembolism in imaging studies. He underwent anticoagulant therapy with significant reduction in thrombus sizes. Conclusion: Hypercoagulation state of COVID-19 disease may lead to serious cardiopulmonary injury.