Peste des petits ruminants (PPR) is a viral transboundary disease of small ruminants that causes significant damage to agriculture. This disease has not been previously registered in the Republic of Kazakhstan (RK). This paper presents an assessment of the susceptibility of the RK’s territory to the spread of the disease in the event of its importation from infected countries. The Generalized Linear Negative Binomial regression model that was trained on the PPR outbreaks in China was used to rank municipal districts in the RK in terms of PPR spread risk. The outbreaks count per administrative district was used as a risk indicator, while a number of socio-economic, landscape and climatic factors were considered as explanatory variables. Summary road length, altitude, the density of small ruminants, the maximum green vegetation fraction, cattle density and the Engel coefficient were the most significant factors. The model demonstrated a good performance in training data (R ² = 0.69) and was transferred to the RK, suggesting a significantly lower susceptibility of this country to the spread of PPR. Hot Spot analysis identified three clusters of districts at the highest risk, located in the western, eastern and southern parts of Kazakhstan. As part of the study, a countrywide survey was conducted to collect data on the distribution of livestock populations, which resulted in the compilation of a complete geo-database of small ruminant holdings in the RK. The research results may be used to formulate a national strategy for preventing the importation and spread of PPR in Kazakhstan through targeted monitoring in high-risk areas.