A man aged 60’s suffered nephrotic syndrome with IgM nephropathy seven years earlier. Four years later, immune-checkpoint inhibitors (ICPIs) were administered against metastasizing pulmonary adenocarcinoma. Sixty-two weeks after 21 ICPIs injections, the cancer vanished but nephrotic syndrome relapsed. Acute pancreatitis followed and usual interstitial pneumonia exacerbated, as late-onset immune-related adverse-events.