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Adjuvant therapy of histopathological risk factors of retinoblastoma in Europe: a survey by the European Retinoblastoma group (EURbG)
  • +37
  • Sabine Dittner-Moormann,
  • Madlen Reschke,
  • Floor Abbink,
  • Isabelle Aerts,
  • Hatice Atalay,
  • Nadezhda Fedorovna Bobrova,
  • Eva Biewald,
  • Ines Brecht,
  • Shani Caspi,
  • Nathalie Cassoux,
  • Guilherme Castela,
  • Yelena Diarra,
  • Catriona Duncan,
  • Martin Ebinger,
  • David Garcia Aldana,
  • Theodora Hadjistilianou,
  • TomĂ¡Å¡ KepĂ¡k,
  • Artur Klett,
  • Hayyam Kiratli,
  • Erika Maka,
  • Enrico Opocher,
  • Jelena Rascon,
  • Katarzyna PawiÅ„ska-WÄ…sikowska,
  • Ida Russo,
  • Olga Rutynowska-Pronicka,
  • Constantino SĂ¡bado,
  • Sonsoles San Roman Pacheco,
  • Karel Svojgr,
  • Beate Timmermann,
  • Vicktoria Vishnevskia-Dai,
  • Angelika Eggert,
  • Petra Ritter-Sovinz,
  • Nicolaos Bechrakis,
  • Helen Jenkinson,
  • Annette Moll,
  • Francis Munier,
  • Maja Beck-Popovic,
  • Guillermo Chantada,
  • Francois Doz,
  • Petra Ketteler
Sabine Dittner-Moormann
University of Duisburg-Essen Faculty of Medicine

Corresponding Author:[email protected]

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Madlen Reschke
Charite Universitatsmedizin Berlin
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Floor Abbink
Amsterdam UMC, Location VU University Medical Centre
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Isabelle Aerts
Institut Curie
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Hatice Atalay
Gazi University, Faculty of Medicine
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Nadezhda Fedorovna Bobrova
Filatov Eye Institute Odessa
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Eva Biewald
Universitatsklinikum Essen
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Ines Brecht
University of TĂ¼bingen
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Shani Caspi
Sheba Medical Center Laboratory Division
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Nathalie Cassoux
Institut Curie
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Guilherme Castela
Centro Hospitalar e UniversitĂ¡rio de Coimbra
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Yelena Diarra
University of Duisburg-Essen Faculty of Medicine
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Catriona Duncan
Great Ormond Street Hospital For Children NHS Foundation Trust
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Martin Ebinger
University Children's Hospital TĂ¼bingen
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David Garcia Aldana
Virgen Macarena University Hospital
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Theodora Hadjistilianou
UniversitĂ  degli Studi di Siena FacoltĂ  di Medicina e Chirurgia
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TomĂ¡Å¡ KepĂ¡k
University Hospital Brno and St. Anna University Hospital/ICRC, Masaryk University
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Artur Klett
East Tallinn Central Hospital
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Hayyam Kiratli
Hacettepe University Faculty of Medicine
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Erika Maka
Semmelweis University
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Enrico Opocher
Padua University Hospital
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Jelena Rascon
Children‘s Hospital, Affiliate of Vilnius University Hospital Santariskiu Klinikos
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Katarzyna Pawińska-Wąsikowska
Department of Pedriatric Oncology and Hematology, Jagiellonian University Medical College
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Ida Russo
Ospedale Pediatrico Bambino Gesu
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Olga Rutynowska-Pronicka
The Children’s Memorial Health Institute
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Constantino SĂ¡bado
Hospital Vall d’Hebron
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Sonsoles San Roman Pacheco
Hospital La Paz
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Karel Svojgr
Univerzita Karlova v Praze 2 lekarska fakulta
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Beate Timmermann
Westdeutsches Protonenthearpiezentrum
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Vicktoria Vishnevskia-Dai
Sheba Medical Center
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Angelika Eggert
Charite Universitatsmedizin Berlin
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Petra Ritter-Sovinz
Mediacal University of Graz
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Nicolaos Bechrakis
University of Duisburg-Essen Faculty of Medicine
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Helen Jenkinson
Birmingham Children's Hospital NHS Trust
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Annette Moll
VU University Medical Center
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Francis Munier
Jules Gonin Eye Hospital, University of Lausanne
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Maja Beck-Popovic
University Hospital
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Guillermo Chantada
Hospital de PediatrĂ­a Prof. Dr. Juan P. Garrahan
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Francois Doz
Institut Curie
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Petra Ketteler
University of Duisburg-Essen Faculty of Medicine
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Abstract

Introduction: Advanced intraocular retinoblastoma can be cured by enucleation, but spread of retinoblastoma cells beyond natural limits of the eye may lead to metastatic disease which is related to a high mortality. Adjuvant therapy after enucleation has been shown to prevent metastasis in children with risk factors for extraocular retinoblastoma. However, histological criteria and adjuvant treatment regimens vary and there is no unifying consensus on the optimal choice of treatment. Method: Data on guidelines for adjuvant treatment in European retinoblastoma referral centres were collected in an online survey among all members of the European Retinoblastoma group (EURbG) network. Extended information were gathered via personal Email communication. Results: Data were collected from 26 centres in 17 countries. Guidelines for adjuvant treatment were in place at 92.3% of retinoblastoma centres. There was a consensus on indication for and intensity of adjuvant treatment among more than 80% of all centres. The majority of centres use no adjuvant treatment for isolated focal choroidal invasion or prelaminar optic nerve invasion. Patients with massive choroidal invasion or postlaminar optic nerve invasion receive adjuvant chemotherapy, while microscopic invasion of the resection margin of the optic nerve or extension through the sclera are treated with combined chemo- and radiotherapy. Conclusion: Indications and adjuvant treatment regimens in European retinoblastoma referral centres are similar but not uniform. Further biomarkers in addition to histopathological risk factors could improve treatment stratification. The high consensus in European centres is an excellent foundation for a common European study with prospective validation of new biomarkers.
09 Dec 2020Submitted to Pediatric Blood & Cancer
09 Dec 2020Submission Checks Completed
09 Dec 2020Assigned to Editor
10 Dec 2020Reviewer(s) Assigned
29 Dec 2020Review(s) Completed, Editorial Evaluation Pending
30 Dec 2020Editorial Decision: Revise Major
14 Jan 20211st Revision Received
14 Jan 2021Submission Checks Completed
14 Jan 2021Assigned to Editor
20 Jan 2021Reviewer(s) Assigned
29 Jan 2021Review(s) Completed, Editorial Evaluation Pending
01 Feb 2021Editorial Decision: Accept