Introduction:Necrotizing Fasciitis (NF) is an aggressive, life threatening, soft tissue infection with an incidence of 0.5 – 1.5 cases per 100,000 population [1]. It is usually due to synergetic polymicrobial infection. Most common causes of NF are trauma, urinary tract disease and perineal abscess [1]. Treatment involves early surgical debridement of infected tissue followed by broad-spectrum antimicrobial therapy and supportive measures [2]. However only few cases of NF associated with intestinal diseases such as perforated colon cancer have been reported [1]. We present a case of colonic cancer complicated by NF of the thigh.