Prognostic Importance of Thrombospondin-1, VEGF, PDGFR- β in Diffuse
Large B-Cell Lymphoma Cases
Abstract
Purpose: We aimed to investigate the relationship between the staining
rates of thrombospondin-1, VEGF and PDGFR-in tissue preparations in
patients diagnosed with DLBCL as a result of lymphadenopathy biopsy and
their clinical features at the time of diagnosis, response to treatment
and prognosis. Materials and Methods: For this purpose, a total of 44
patients with a diagnosis of DLBCL, 24 male and 20 female, and 13
patients diagnosed with control reactive lymphadenopathy, 6 male and 7
female were enrolled. After the pathology preparations of the patient
and control groups were stained immunohistochemically with VEGF,
PDGFR-β, thrombospondin-1 stains, the clinical characteristics of the
patients and the relationship between survival analysis and staining
rates were analyzed statistically. Results: When the patients were
compared with the control group in terms of VEGF, PDGFR-β,
thrombospondin-1 staining rates, we found that staining with PDGFR-β was
lower in patients (p = 0.009). Although it was not statistically
significant for PDGFR-β, it was observed that 5-year OS and PFS values
were low in patients with high levels of expression, on the contrary,
5-year OS was low in patients with high thrombospondin staining rate. A
negative correlation was seen between thrombospondin-1 and PDGFR-β
(p=0.003, r=-0.440). Conclusion: As a result, although no relationship
was found between VEGF and survival in our study, it was observed that
PDGFR-β and thrombospondin-1 were effective in prognosis. A negative
correlation was seen between thrombospondin-1 and PDGFR-β.