Lactobacillus can lead to serious infection in individuals with multiple predisposing factors. Therefore, individuals with risk factors, including steroid use, and those harboring immunocompromised conditions such as hypothyroidism and cancer, should be promptly evaluated and appropriate treatment should be initiated without delay if the culture test is positive for Lactobacillus.

Distinguishing between late-onset TINU syndrome and drug-induced AIN remains difficult given that patients with TINU syndrome may develop uveitis long after the onset of AIN. Therefore, ophthalmic examination is required not only upon diagnosis but also continuously or when eye symptoms, and relapse of urinary findings are observed.