Key Points Transoral resection for oral cavity and oropharyngeal cancer has become popular. Transoral conventional interrupt knot tying suturing for oral/oropharyngeal defect often requires time. Transoral barbed knotless continuous suture could reduce operation time with a comparable complication rate. Knotless barbed suture provides appropriate tension and secure closure with multiple anchors. Transoral barbed knotless suture is particularly advantageous in deep and narrow areas.