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An external validation of C-reactive protein reduction as a predictor of healing following laryngopharyngectomy
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  • Tobias James,
  • Michael Edwards,
  • Hannah Nieto,
  • Hisham Mehanna,
  • Paul Pracy,
  • Christopher Jennings,
  • Neil Sharma,
  • Paul Nankivell
Tobias James
James Cook University Hospital

Corresponding Author:[email protected]

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Michael Edwards
University Hospitals Birmingham NHS Foundation Trust
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Hannah Nieto
University Hospitals Birmingham NHS Foundation Trust
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Hisham Mehanna
University Hospitals Birmingham NHS Foundation Trust
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Paul Pracy
Queen Elizabeth Hospital, University Hospitals Birmingham NHS Foundation Trust
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Christopher Jennings
Queen Elizabeth Hospital
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Neil Sharma
University of Birmingham
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Paul Nankivell
Queen Elizabeth Hospital Birmingham
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Abstract

Key Points • CRP reduction at day five of more than 35% from the previous highest concentration post-laryngectomy or laryngopharyngectomy has been proposed to positively predict healing without pharyngocutaneous fistula • Retrospective cohort analysis of 163 patients has not been able to externally validate these findings. • ROC curves and subset analyses have not identified alternative parameters to reach significance • However, there is a non-significant association with decreasing postoperative CRP and healing without fistula. • Multicentre prospective studies to include post-operative procalcitonin could help refine this protocol further.
22 Mar 2022Submitted to Clinical Otolaryngology
24 Mar 2022Submission Checks Completed
24 Mar 2022Assigned to Editor
04 Apr 2022Reviewer(s) Assigned
28 Apr 2022Review(s) Completed, Editorial Evaluation Pending
04 Jun 2022Editorial Decision: Accept
10 Aug 2022Published in Clinical Otolaryngology. 10.1111/coa.13966