Although rare, the association between simple bone cysts and cemento-osseous dysplasia is very important to know. It is essential to be able to establish a correct diagnosis through regular follow-up to detect clinical and radiological changes of this entity over time and to be able to intervene when necessary.

MTA® is considered as the biomaterial of choice because of its excellent characteristics. Recently, Biodentine™ has been introduced into periapical surgery and has proven its efficacity in sealing root-end-cavities. Despite of the desirable properties of Biodentine™, there are limited published cases that described the use of Biodentine™ in periapical surgery.