Background Myxomas are the most common form of benign primary cardiac tumor, most of them are located in the left atrium. When they are located in the right atrium, It may occur with pulmonary artery embolism. Methods and Results A 72-year-old woman had endured more than 5 months with chest tightness and difficulty breathing. Based on various clinical findings and data, we diagnosed this subject as Cushing’s syndrome. Emergency bedside ultrasound showed right atrial tumor, which was confirmed by coronary computed tomography angiography (CCTA).The patient underwent surgical resection of the right atrial and pulmonary artery tumors.In the two subsequent short-term reviews (one month and half a year after surgery), we found same new myxoma in the atrial septum and pulmonary nodules. Discussion Tumor recurrence is uncommon, although not unknown, after complete excision. Recurrence following surgical excision is rare, with an incidence of only 1%–3% of all myxomas, and the postoperative course is generally good. However, some myxomas occur as part of a syndrome known as Carney complex, which have some unusual features. Conclusion They face a mottled skin pigmentation, and gorgeous features of Cushing’s syndrome. Myxomas recurrence have been reported in numerous reports. In contrast with other reported cases, a specific characteristic of the present case was the short-term recurrence of Cardiac myxoma and newly grown nodules in the lungs. Patients received our recommendations for lifetime anticoagulation therapy and long-term follow-up observations.