Disaster risk reduction relies on quantitative estimates of the future impacts and consequences of known hazard threats in order to evaluate proposed mitigation and adaptation measures. Natural Resources Canada is collaborating with the Global Earthquake Model Foundation on the first ever national seismic risk assessment in Canada to inform disaster risk reduction planning by individuals, businesses and organizations working across all jurisdictional levels. The 2020 National Seismic Risk Model incorporates the 6th Generation National Seismic Hazard Map, a novel physical exposure model for the entire country, localized exposure models based on a machine learning approach to building categorization, and HAZUS-based earthquake building performance functions. Before results can be transmitted to end users, the model must be validated in a Canadian context using observations from real world disaster events or pre-existing catastrophic risk models. This study focuses on benchmarking the 2020 Canadian National Seismic Risk Model using shaking intensities and physical impacts recorded from the 2001 Mw 6.8 Nisqually and 2012 Mw 7.8 Haida Gwaii events, and the results of a 2013 catastrophic risk assessment performed by AIR Worldwide to evaluate the potential impact of major earthquakes in eastern Quebec and Cascadia. We compute anticipated building damage, economic loss, and fatalities for these benchmark scenario earthquakes using the OpenQuake engine and the national exposure dataset. Preliminary results indicate that the model results are largely consistent with observed or predicted impacts of these earthquakes in Canada, after adjusting for economic and population growth. Subsequently, we will evaluate the impact of running the Cascadia scenario using a regional building-level exposure database versus the national level inventory. Ultimately, this work will assess the ability of the National Seismic Risk Assessment to reproduce expected results, to ensure the applicability of this model in anticipating future outcomes at the national and local level.