Pakistan struggles to eliminate poliomyelitis. There are some principal tasks to deal with, including ending transmission in central reservoirs, enduring pressure to exploit the quality of Supplemental Immunization Activity [SIA], handling in critical Community Based Vaccination [CBV] and mobile team areas, and covering high-risk mobile residents to avoid additional spread. Due to the discovery and availability of vaccinations, polio is currently considered almost eliminated. Positive effects include continual reviews of communication, observation, and control mechanisms, enhanced coordination between the Polio Eradication Initiative [PEI] and the Expanded Program on Immunization [EPI], and a stronger emphasis on strengthening relationships with other service workers in high-risk regions. To eradicate polio, politicians, community mobilizers, government, public health specialists, and education departments must collaborate to better grasp the issue and operate more effectively. The high-level political leadership and promise detailing Pakistan’s response to COVID-19 is the best practical strategy to achieve PEI’s fundamental goals.