Cancer is a disease with high incidence. Other therapies as surgery and radiotherapy is also used in the treatment of this disease. However, the effect adverse and the metastasis limited the use of these therapies. Target anticancer Targeted cancer treatment is an attractive approach where drugs or other substances which targets specific molecules to block the growth and spread of cancer cells. Identification of targets is essential for a successful development of molecular targeted therapies in cancer. This review summarizes current knowledge on the molecules target and the up to date of drugs in clinic assays as Targeted Anticancer Therapies.