Recent studies have reported that coronavirus disease-2019 (COVID-19) vaccination can exacerbate asthma. Status asthmaticus sometimes induces takotsubo cardiomyopathy. We present a case of takotsubo cardiomyopathy triggered by asthma exacerbation after the mRNA-based vaccination. Therapies for status asthmaticus resulted in prompt improvement of respiratory failure and cardiac-apex ballooning.