The rapidly melting Totten Glacier of East Antarctica drains a basin containing ~3.5 m sea-level rise equivalent of ice, but the Totten Glacier dynamics and interaction with the Southern Ocean since the Last Glacial Maximum is not well understood. To better understand the response of the glacier to present and future climate changes, an accurate reconstruction of the retreat history of the Totten Glacier is needed. Hence, this study uses a multiproxy approach in analyzing beryllium isotopes, the first such record from this location, and grain size of a sediment core collected from the continental slope adjacent to Totten Glacier. The results, when evaluated together with nearby proxy records, reveal that the initial deglaciation of the Totten Glacier sector of the East Antarctic Ice Sheet began at ~18 ka BP. The rapid deglaciation from ~9 ka BP that followed is assumed to be caused by the intrusion of modified Circumpolar Deep Water to the grounding zone of the Totten Glacier. This intrusion may also be coupled with a weaker Antarctic Slope Current and southward shift of Antarctic easterlies. This result contributes to the body of knowledge regarding the dynamical response of marine-terminating glaciers to climate variability during the last deglaciation.