Cardiofaciocutaneous syndrome is a rare genetic disorder. It is characterized by craniofacial dysmorphism, congenital heart disease, ectodermal abnormalities, developmental delay, and central nervous system disorders. We discuss the case of an 11-year-old boy with cardiofaciocutaneous syndrome presenting with ulerythema ophryogenes and phenotypic features similar to Noonan syndrome.

LSA and morphea are chronic diseases, characterized by the sclerosis of the connective tissues. Bullous type of both diseases and coexistence of LSA and morphea are very rare manifestations. Herein. we report a case consistent with bullous combined LSA and morphea that was treated with methotrexate and pulse of methylprednisolon