Tim Bierewirtz

and 8 more

Objective: Total artificial hearts (TAH) are used as a temporary treatment for severe biventricular heart failure. Long-term cardiac replacement is hampered by limited durability and complication rates, which may be attributable to the modus operandi of state-of-the-art pumping systems. The aim of this study was to assess the feasibility of a novel valveless pumping principle for a durable pulsatile TAH (ShuttlePump). Methods: With a rotating and linearly shuttling piston within a cylindrical housing with 2 in- and outlets, the pump features only one single moving part and delivers pulsatile flow to both systemic and pulmonary circulation. The pump and actuation system were designed iteratively based on analytical and in silico methods, utilizing finite element methods (FEM) and computational fluid dynamics (CFD) Pump characteristics were evaluated experimentally in a mock circulation loop mimicking the cardiovascular system, while hemocompatibility related parameters were calculated numerically. Results: Pump characteristics cover the entire required operating range for a TAH (2.5 - 9L/min at 50 - 160mmHg arterial pressures) at stroke frequencies of 1.5 - 5Hz while balancing left and right atrial pressures. FEM analysis showed a mean overall copper losses of 8.84W, resulting in local blood temperature rise of < 2k. The CFD results of normalized index of hemolysis was 3.57 mg/100L and 95% of the pumps blood volume was exchanged after 1.42s. Conclusion: This study indicates feasibility of a novel pumping system for a TAH with numerical and experimental results substantiating further development of the ShuttlePump.

Daifei Zhang

and 3 more

Universal high-power three-phase mains interfaces for electric vehicle (EV) charging must provide a wide output voltage range (e.g., 200V to 800V) and thus provide buck and boost capability. An advantageous realization combining a three-level (3-L) T-type (Vienna) boost-type PFC voltage-source rectifier (VSR) with a 3-L buck-type DC/DC converter stage is presented in this paper. For high output voltages (boost-mode), the VSR-stage operates with 3/3-PWM, i.e., continuous PWM of all three phases to regulate the output voltage while the DC/DC-stage remains clamped to avoid switching losses. For low output voltages (buck-mode), the DC/DC-stage advantageously controls the DC-link voltage according to a time-varying reference value, which allows to sinusoidally shape the currents of two mains phases, such that the VSR-stage can operate with 1/3-PWM (only one of the three bridge-legs operates with PWM at any given time) with reduced switching losses. This paper proposes a novel 2/3-PWM scheme for the output voltage transition region, where output voltages are between the buck-mode and the boost-mode. This enables loss-optimum operation (i.e., the minimum number of the VSR-stage bridge-legs operating with PWM, and with the minimum possible DC-link voltage) for any output voltage. Furthermore, this paper introduces a new synergetic control concept that ensures seamless transitions between the loss-optimum operating modes. A comprehensive experimental verification, including pre-compliance EMI measurements, using a 10-kW hardware demonstrator with a power density of 5.4kW/L, a peak efficiency of 98.8% at rated power and 560V output voltage, and >98% efficiency for all operating points with >400V output voltage and more than about 50% of rated power, confirms the theoretical analyses.