Title: ‘Hydropneumothorax as an Rare Manifestation of Secondary Hypereosinophilic Syndrome - A Case Report’Prakash Sapkota, Bhuwan Thapa, Aseem Bhattarai, Sujata Chalise, Sajana K C, Ashish TamangAbstract :We present a case of a young man who presented with cough and shortness of breath for two weeks with peripheral eosinophilia of unknown cause leading to left-sided pleural effusion. He was initially administered antiparasitic drugs (Ivermectin and Praziquantel). After one week the patient presented with an acute increase in SOB and was diagnosed with bilateral hydropneumothorax. A bilateral pigtail was inserted. Pleural fluid analysis was done which was purulent with lymphocyte predominance and high adenosine deaminase. The patient was treated with anti-tubercular therapy and steroids. After six months of therapy, the patient was asymptomatic. The hypereosinophilic syndrome can be presented in several ways and this study presented in a distinct way via hydropneumothorax.