Prevalence Characteristics of Non-16/18 Human Papillomavirus in Fujian,
China: A 11-year survey of 101621 women
Abstract
This retrospective cohort study in Fujian Province aimed to investigate
the prevalence and characteristics of non-16/18 HPV infections and their
correlation with cervical lesions. Data from 101,621 patients (24,924
HPV positive) over 2012-2022 were analyzed. HPV genotypes, age-specific
rates, and cervical pathology were assessed in 11,666 patients
undergoing pathological exams. The results revealed that non-16/18 HPV
infections, particularly HPV 52, 58, 53, 51, and 81 (with prevalence
rates of 5.6%, 2.6%, 2.4%, 2.3%, and 2.2%, respectively), were
widespread in the region. The main infection type was single infection
rather than complex infection. The age distribution of subgroups with
non-16/18 HPV infections shows variations over time, with different peak
infection rates across the years. The highest prevalence of non-16/18
HPV infections was observed in patients with low-grade squamous
intraepithelial lesions (LSIL). Conversely, HPV16/18 infections were
more likely to cause high-grade squamous intraepithelial lesions (HSIL)
and cervical cancer. Although the 9-valent HPV vaccine was found to
provide broad protection against HPV infections, it did not cover
certain non-16/18 HPV types, such as HPV53, HPV51, and HPV81, which
remained prevalent. This study aids in optimizing cervical lesion
detection and enhancing cervical cancer risk management for non-16/18
HPV infections in Fujian.