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Respiratory Torque Teno Virus load at Emergency department visit predicts intensive care unit admission of SARS-CoV-2 infected patients
  • +6
  • Jerome LeGoff,
  • Linda Feghoul,
  • Amandine Caillault,
  • Olivier Peyrony,
  • Maud Salmona,
  • Marie-Laure Nere,
  • Constance Delaugerre ,
  • E. Azoulay,
  • Sylvie Chevret
Jerome LeGoff
Hopital Saint-Louis

Corresponding Author:[email protected]

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Linda Feghoul
Hopital Saint-Louis
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Amandine Caillault
Hopital Saint-Louis
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Olivier Peyrony
Assistance Publique - Hopitaux de Paris
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Maud Salmona
Hopital Saint-Louis
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Marie-Laure Nere
Hopital Saint-Louis
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Constance Delaugerre
Hopital Saint-Louis
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E. Azoulay
Hopital Saint-Louis
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Sylvie Chevret
Centre de Recherche en Epidemiologie et Statistiques Sorbonne Paris Cite
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Abstract

Background: Accurate prediction of SARS-CoV-2 severity remains a challenge. Torque Teno Virus (TTV), recognized as a surrogate marker for cellular immunity in solid organ transplant recipients, holds potential for assessing infection outcomes. Objectives: We investigated whether quantifying TTV in nasopharyngeal samples upon emergency ward (ED) admission could serve as an early predictor of SARS-CoV-2 severity. Study design: Retrospective single-center study in the ED of Saint-Louis Hospital in Paris, France. TTV DNA was quantified in nasopharyngeal swab samples collected for SARS-CoV-2 testing. Results: Among 295 SARS-CoV-2 infected patients, 92 returned home, 160 were admitted to medical wards, and 43 to the intensive care unit. Among 295 SARS-CoV-2 patients, 92 were discharged, 160 hospitalized, and 43 admitted to the intensive care unit (ICU). Elevated TTV loads were observed in ICU patients (Median: 3.02 log copies/mL, interquartile range [IQR]: 2.215-3.825), exceeding those in discharged (2.215, [0; 2.962]) or hospitalized patients (2.24, [0; 3.29]) (p=0.006). Multivariate analysis identified diabetes, obesity, hepatitis, fever, dyspnea, oxygen requirement, and TTV load as predictors of ICU admission. A 2.91 log 10 copies/mL TTV threshold independently predicted ICU admission. Conclusion: Nasopharyngeal TTV quantification in SARS-CoV-2 infected patients is linked to the likelihood of ICU admission and might reflect respiratory immunosuppression.
05 Aug 2023Submitted to Journal of Medical Virology
08 Aug 2023Submission Checks Completed
08 Aug 2023Assigned to Editor
08 Aug 2023Review(s) Completed, Editorial Evaluation Pending
16 Aug 2023Reviewer(s) Assigned
24 Aug 2023Editorial Decision: Revise Major
27 Sep 20231st Revision Received
28 Sep 2023Submission Checks Completed
28 Sep 2023Assigned to Editor
28 Sep 2023Review(s) Completed, Editorial Evaluation Pending
16 Oct 2023Reviewer(s) Assigned
24 Oct 2023Editorial Decision: Revise Minor
31 Oct 20232nd Revision Received
31 Oct 2023Submission Checks Completed
31 Oct 2023Assigned to Editor
31 Oct 2023Review(s) Completed, Editorial Evaluation Pending
08 Nov 2023Reviewer(s) Assigned