Colorectal cancer (CRC) ranks among the top three most prevalent and lethal cancers for men and women. The overall annual CRC incidence rate has decreased Since 1985. However, despite continued overall declines, CRC is rapidly shifting to diagnosis at a younger age. Studies suggest that there were significant differences of early-onset CRC in epidemiology, etiology, molecular features, it is a heterogeneous disease. So further characterization of early-onset CRC is required to reveal the difference in clinical and pathological characteristics as well as prognosis between the 2 groups. It may help improve the treatment strategy in the future.