Deinococcus wulumuqiensis R12 synthesized silver nanoparticles with
peroxidase-like activity for synergistic antibacterial application
- Jingjia Liu,
- Nan Zhang,
- Bowen Shen,
- Liling Zhang,
- Zhidong Zhang,
- Liying Zhu,
- Ling Jiang
Abstract
The use of a combination of several antibacterial agents for therapy
holds great promise in reducing the dosage and side effects of these
agents, improving their efficiency, and inducing potential synergistic
therapeutic effects. Herein, R12-AgNPs were produced with the
supernatant of an ionizing radiation-tolerant bacterium Deinococcus
wulumuqiensis R12 by one-step under room temperature. The biosynthesized
AgNPs presented fascinating antibacterial activity and peroxidase-like
properties, which endowed it with the capability to catalyse the
decomposition of H2O2 to generate hydroxyl radical. After combination of
R12-AgNPs and H2O2, an excellent synergistic bacteriostatic activity was
observed for both E. coli and S. aureus, especially at low
concentrations. In addition, in vitro cytotoxicity tests showed
R12-AgNPs had good biocompatibility. Thus, this work presents a novel
antibacterial agent that exhibits favorable synergistic antibacterial
activity and low toxicity, without the use of antibiotics or a
complicated synthesis process.27 Oct 2023Submitted to Biotechnology Journal 27 Oct 2023Submission Checks Completed
27 Oct 2023Assigned to Editor
27 Oct 2023Review(s) Completed, Editorial Evaluation Pending
28 Oct 2023Reviewer(s) Assigned
06 Mar 2024Review(s) Completed, Editorial Evaluation Pending
06 Mar 2024Reviewer(s) Assigned