YAP/TAZ are two homologous transcriptional coactivators that promote cell proliferation, stem cell maintenance, and tissue homeostasis. Activated YAP/TAZ reflects the “social” behavior of cells, including cell adhesion and mechanical signals that cells receive from tissue structures and the surrounding extracellular matrix (ECM). Simultaneous activation or overexpression of YAP/TAZ has been shown to lead to cellular transformation and tumor development. Intestinal diseases are mostly inflammatory and tumor-based, and YAP/TAZ plays an important role in this process. However, many roles of the YAP/TAZ in the course of intestinal disease are not clear. Therefore, this paper discusses the YAP/TAZ-binding proteins, involved pathways, and related pathological processes in the development of inflammatory bowel disease and intestinal cancer disease.