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Public Documents
1
Combination Therapy for Unresectable Primitive Myxoid Mesenchymal Tumor of Infancy: A...
Trevor Memmott
and 3 more
January 31, 2024
Primitive myxoid mesenchymal tumor of infancy is a rare, locally aggressive, chemotherapy-refractory pediatric sarcoma with a high morbidity and mortality rate. Surgical resection is the gold standard of treatment, but a significant number of cases are initially unresectable due to tumor location. For these individuals, traditional first-line chemotherapy with vincristine, actinomycin, and cyclophosphamide has yielded no benefit. Alternatively, therapy with doxorubicin and ifosphamide-based regimens have shown success in several cases. We present a case of a pediatric patient with unresectable PMMTI successfully cured after receiving a combination of ifosphamide and doxorubicin followed by surgery and adjunctive proton beam radiation.