Early detection of cancer predisposition syndromes (CPS) is crucial to determine optimal treatments and follow-up, and to provide appropriate genetic counseling. This study outlines an approach in a pediatric oncology unit, where 50 randomly selected patients underwent clinical assessment, leading to 44 eligible for genetic testing. We identified 3 pathogenic or likely pathogenic variants in genes associated with CPS and 6 Variants of Uncertain Significance (VUS) potentially associated with cancer development. We emphasize the importance of a thorough and accurate collection of family history and physical examination data and the full coordination between pediatric oncologists and geneticists.

Introduction: Radiotherapy is an underutilized resource in pediatric palliative care; however, it is useful in relieving various symptoms at the end of life. Patients and methods: A retrospective study of 30 pediatric patients who received radiotherapy for palliative reasons is shown. The objective was to review whether radiotherapy was beneficial. Results: Radiotherapy was useful in relieving symptoms, showing an overall response in 87% of cases and with mild toxicities. The poorest responses were in gliomas with relief in 56% of cases showing toxicity in 89%. The need for anesthesia and irradiation at early ages were predisposing factors for the development of toxicities. Conclusions: The use of palliative radiotherapy is beneficial and should be included in the multidisciplinary management of the child in palliative care.