IntroductionCoccidioidomycosis, known as Valley Fever, is the disease caused by the inhalation of arthroconidia from the soil-dwelling dimorphic fungi,Coccidioides immitis and Coccidioides posadasii [1]. In the United States, coccidioidomycosis is endemic to the southwestern part of the country, with most cases located in the San Joaquin Valley of California and Southern Arizona. The incidence of coccidioidomycosis is approximately 10,000 cases reported annually [1,2]. Coccidioidomycosis may affect any demographic, but primarily affects those aged 40-60 years old and has a slight male predominance. Clinical manifestations range from asymptomatic to disseminated infection depending on the patient’s immune status.Cutaneous manifestations in coccidioidomycosis can be classified as reactive or organism-containing lesions in secondary or primary cutaneous infection [3]. Sweet syndrome, or acute febrile neutrophilic dermatosis, is an inflammatory, non-infectious skin reaction rarely observed as one of the reactive skin manifestations of coccidioidomycosis. Patients with Sweet syndrome clinically present with fever, leukocytosis with neutrophilia, and painful erythematous papules, plaques, pustules, and nodules commonly appearing on the upper limbs, trunk, head, and neck [4]. Here, we present a case of coccidioidomycosis associated with Sweet’s syndrome.