Sweet’s Syndrome (SS) is an inflammatory skin condition characterised by sudden onset of fever, painful skin lesions and neutrophilic infiltration of affected tissues. The systemic association of SS include infections, drugs, malignancy and autoimmune disorders. The diagnosis requires prompt clinical suspicion followed by histopathological confirmation. We describe a case of a 6-year-old boy with relapsed acute myeloid leukaemia (AML) presenting with the fever and diffuse erythematous papules over the face, neck, trunk, arms and legs. Early identification and histological confirmation aided treatment of above condition. The clinical rarity, diagnostic clues and a brief review of published literature has been described.