Welcome to this Special Issue of Wiley’s Healthcare Technology Letters (HTL) journal dedicated to the 2023 edition of the Augmented Environments for Computer-Assisted Interventions (AE-CAI), Computer Assisted and Robotic Endoscopy (CARE), and Context-aware Operating Theatres (OR 2.0) joint workshop. We are pleased to present the proceedings of this exciting scientific gathering held in conjunction with the Medical Image Computing and Computer-Assisted Interventions (MICCAI) conference on October 8th, 2023 in Vancouver, British Columbia, Canada. We hope that you will enjoy reading this Special Issue and we look forward to your continuing support and participation in future editions of the AE-CAI, CARE and OR 2.0 workshops. Their continued success demands our ongoing commitment and support, and we hope to welcome you all to the next edition of the workshop at MICCAI 2024 in Marrakesh, Marocco.