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Antonella Brunello
Public Documents
1
High-dose continuous infusion ifosfamide in the treatment of bone marrow infiltration...
Fabio Murtas
and 11 more
April 26, 2024
Ewing sarcoma is a rare primary mesenchymal tumor of the bone that requires an intensive multimodal therapeutic approach. Multidrug chemotherapy regimens are also the backbone for relapsing/recurring Ewing sarcoma treatment, yet when relapse occurs as bone marrow infiltration, combination chemotherapy might be difficult to be administered and prognosis is poor. This report describes the case of a 22-year-old patient with Ewing sarcoma who developed severe pancytopenia due to bone marrow infiltration, who was treated with high-dose continuous infusion ifosfamide, obtaining both clinical, radiological and hematological response lasting for about 7 months.