In the rapidly advancing landscape of System-on-Chips (SoCs), achieving appropriate levels of functional safety compliance has become a fundamental concern. With SoCs serving critical roles in applications such as automotive, industrial, and consumer electronics, a unified approach to navigate different functional safety standards can help save time and speed up time to market. By reusing the fundamental principles of ISO 26262 and IEC 61508, this article presents a unified framework tailored specifically for advanced multi-domain SoCs. This framework seeks to streamline safety compliance efforts while enhancing overall system safety resilience for various applications.