Introduction Chorioangioma is a benign vascular tumor of the placenta that occurs in approximately 1% of pregnancies1. The majority of cases are small and asymptomatic, with symptoms appearing in only 0.01%–0.03% of instances2. Giant chorioangiomas, defined as tumors larger than 4 cm, are remarkably rare, with a prevalence ranging from 1:9,000 to 1:50,000 3. While many chorioangiomas are detected during postnatal examination of placental histology, large chorioangiomas are associated with significant maternal and fetal complications. These include preterm labor, intrauterine growth restriction (IUGR), pre-eclampsia, polyhydramnios as well as hydrops fetalis, disseminated intravascular coagulation (DIC), and mortality 4–6.Despite significant advancements in therapeutic approaches, perinatal mortality rates remain high, estimated to be more than 30%7. Therefore, it is essential to highlight the importance of timely identification, comprehensive prenatal monitoring, and appropriate interventions to prevent fetal morbidity and mortality8. In this report, we present a case involving multiple giant chorioangiomas in a 23-year-old woman, which were associated with fetal complications and ultimately resulted in the neonate’s death due to hydrops fetalis. This case emphasizes the complexity of this condition and underscores the necessity for a multidisciplinary approach in evaluating and counseling patients with intricate fetal anomalies. This study has been reported in line with the CARE criteria9.