Abstract

Wnt5a plays an important role in the process of cell development and maturation and is closely related to various diseases, such as malignant tumors, metabolic disorders, fibrosis, growth and development. Recent studies have shown that Wnt5a expression regulation and signal transduction are closely related to inflammatory response. This paper comprehensively reviews the latest research progress on the relationship between Wnt5a and various inflammatory diseases, such as sepsis, asthma, chronic obstructive pulmonary disease, tuberculosis, rheumatoid arthritis, atherosclerosis, psoriasis vulgare, etc. The mechanism of Wnt5a protein in the pathogenesis of these diseases was elucidated, which provided a basis for the prevention and treatment of inflammatory diseases with Wnt5a as a possible target in the future.