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A systematic review of interventions for neurocognitive dysfunctions in patients and survivors of a pediatric brain tumor.
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  • Kristien Bullens,
  • Sleurs Charlotte,
  • Jeroen Blommaert,
  • Jurgen Lemiere,
  • Sandra Jacobs
Kristien Bullens
Katholieke Universiteit Leuven Departement Oncologie
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Sleurs Charlotte
Katholieke Universiteit Leuven Departement Oncologie
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Jeroen Blommaert
Katholieke Universiteit Leuven Departement Oncologie
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Jurgen Lemiere
Katholieke Universiteit Leuven Departement Oncologie
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Sandra Jacobs
Katholieke Universiteit Leuven Departement Oncologie

Corresponding Author:[email protected]

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Abstract

Due to a high burden of neurocognitive impairment on patients with a pediatric brain tumor, interventions mitigating these symptoms are highly needed. Currently, evidence on the efficacy and feasibility of such interventions remain scarce. A systematic literature study was performed based on four different databases (PubMed, Web of Science Core Collection, Embase and PsycArticles). Resulting articles (n=2232) were screened based on title and abstract, and full text. We included 28 articles, investigating cognitive effects of either a lifestyle intervention (n=6), a cognitive training (n=15), or pharmacological intervention (n=7). The most frequently studied interventions were the Cogmed and methylphenidate. Most interventions showed short-term efficacy. Fewer interventions also showed long-term maintenance of positive results. Despite positive trends of these interventions, results are heterogeneous, suggesting relatively limited efficacy of existing interventions and more potential of more individualized as well as multimodal approaches for future interventions.
Submitted to Pediatric Blood & Cancer
Submission Checks Completed
Assigned to Editor
Reviewer(s) Assigned
28 Jun 2024Reviewer(s) Assigned
29 Jul 2024Review(s) Completed, Editorial Evaluation Pending
30 Jul 2024Editorial Decision: Revise Major
02 Sep 20241st Revision Received
02 Sep 2024Submission Checks Completed
02 Sep 2024Assigned to Editor
02 Sep 2024Review(s) Completed, Editorial Evaluation Pending
02 Sep 2024Editorial Decision: Accept