not-yet-known not-yet-known not-yet-known unknown In a space station, to ensure the thermal comfort of users, to get rid of infectious contaminants, and to find a solution to the dissipation of body heat, it is necessary to maintain a homogeneous distribution of the air flow under microgravity conditions in a closed environment. In this work, computational fluid dynamic (CFD) methods were applied to study the distribution of airflow and thermal comfort inside an empty room in a space station under microgravity condition. Numerical simulation is performed using a commercial computational fluid dynamic (CFD) package ANSYS CFX software to understand the effect of inlet flow angle change and, air velocity on the performance of the space station thermal comfort. The comfort level was evaluated using the effective draft temperature (EDT) according to ASHRAE (55-210). the scaled down model, are 0.4 × 0.4 × 1.44 m 3. The scale model featured supply inlet and exhaust outlet dimensions of 100 mm × 18 mm and 168 mm × 18 mm, respectively.The simulation results and the relevant data from the literature were in good agreement. The results showed that (i) Comfort zones are defined by speed ranges from 0.036 m/s to less than 0.076 m/s. When the air supply angle was set at 45°, the cabin space exhibited the highest percentage of speeds falling within the comfort range. (ii) The 35 ° air supply angle exhibited the most optimal performance. (iii) The air supply angle was set at 45 °, which gives the best effective draft temperature (EDT) that satisfies the ASHRAE 55-210 criteria: -1.7 EDT 1.1 and 0.076m / s V 0.0203m / s.