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SARA NAIM
Public Documents
1
Unusual Bone Metastasis Neuroblastoma in Adolescent with Unidentified Primary Site
SARA NAIM
and 8 more
August 25, 2024
Introduction:Neuroblastoma (NB) is the most common extracranial solid tumor in children. The median age at diagnosis was 19 months. It is characterized by clinical heterogeneity. Depending on the risk group, treatment ranges from observation to aggressive multimodal treatment. Stage and age are clinically predictive of outcome. Younger patients (usually defined as 18 months or younger) fared better [1]. Imaging is used to assess primary tumors and determine patterns of disease spread. 60% of tumors originate in the abdomen, with adrenal glands in 32% of cases; other sites are the chest (15%), pelvis (5%), neck (5%), and rarely the brain (1%). [2] Bone and bone marrow are the most common sites of metastatic disease, involving skeletal structures ranging from the skull and spine to the appendix skeleton, followed by the liver and skin. [3]We present a rare case of a patient with bone metastasis neuroblastoma of unknown primary site.