Perovskite solar cells (PSCs) have attracted considerable attention due to their potential for high-efficiency conversion and cost-effective fabrication. Although the fabrication of perovskite films in ambient air offers environmental and cost advantages, the presence of water vapor and oxygen may induce instability in these films, thereby affecting device performance. This review aims to comprehensively explore recent advancements in the fabrication of PSCs in ambient air, while investigating various factors contributing to perovskite degradation. Addressing these challenges, diverse fabrication strategies are outlined, encompassing compositional, additive, solvent, and interface engineering to enhance the performance and stability of PSCs fabricated under ambient air. To facilitate the commercialization of PSCs, this paper summarizes several widely employed methods for the large-scale manufacturing of PSCs. Through this review, we aim to offer some invaluable insights and guidance for the commercialization trajectory of PSCs, as well as the pros and cons to their widespread applications in the field of renewable energy.