not-yet-known not-yet-known not-yet-known unknown Fatigue characterization of asphalt mixtures is imperative for predicting pavement performance. Since cracking begins in asphalt binders, determining their fatigue properties helps establish cause-and-effect relationships with cracking in mixtures and pavements. This study analyzes the fatigue of 12 Brazilian asphalt binders and mixtures using the Linear Amplitude Sweep (LAS) test for binders and the Direct Tension Cyclic Fatigue test for mixtures. Results were interpreted with Simplified Viscoelastic Continuous Damage theory (S-VECD) and a pavement was simulated using FlexPAVE TM software. Findings indicate that binder type alone does not predict fatigue class through the fatigue factor of binder (FFB), necessitating rheological damage analysis. Most mixtures showed good performance in pavement simulations, with fatigue factor of mixtures (FFM) and fatigue classes not being sufficient for predicting fatigue performance. A linear correlation was found between FFB and FFM but not between FFB and simulated damage (N/Nf), though higher FFB typically result in lower N/Nf.