IntroductionThe celiac plexus is a visceral nerve bundle located behind the pancreas. It overlies the anterolateral surface of the aorta and innervates many visceral organs, including the pancreas. The plexus has been established as a targeted area for therapy in pancreatic cancer1. Celiac Plexus Block (CPB) is a minimally invasive procedure that has been shown to reduce pain and improve quality of life in patients. The implementation of Early versus Delayed CPB has also been studied; use of an Early CPB has been shown to decrease overall narcotic consumption and reduce adverse effects due to analgesic use when compared to Delayed CPB2. Early CPB is defined as an intervention initiated promptly once a patient meets the criteria, with abdominal pain being the most common indicator3,4. Delayed CPB takes a wait-and-see approach and is only implemented when the patient develops persistent refractory pain or has intolerable adverse effects from analgesics4. This article presents a case in which early CPB was performed in a 73-year-old female that had pancreatic adenocarcinoma with lung metastases. The patient presented to CentraState Medical Center (CSMC) and underwent the procedure prior to onset of recalcitrant abdominal pain and need for a long course of analgesics. Early interventional treatment has been shown to be extremely beneficial in cancer patients5. This case report adds to the current belief that intervention with CPB should be early in patients with pancreatic cancer and will benefit them more than a wait-and-see approach by decreasing adverse effects from analgesics, improving patient comfort, and allowing for better patient care.