The exponential rise in cyber threats has escalated the urgency for robust, automated defenses capable of identifying and mitigating sophisticated ransomware attacks. Current detection systems, predominantly reliant on static or rule-based methodologies, often fall short in recognizing rapidly evolving ransomware variants, necessitating adaptive solutions that address both accuracy and computational efficiency. In response, an innovative framework combining Adaptive Anomaly Clustering (AAC) with Threat Signature Prediction (TSP) is proposed to deliver a dynamically adaptive ransomware detection model. The AAC component isolates malicious activities through behavior-specific clustering, achieving high specificity in identifying ransomware, while TSP predicts potential ransomware signatures in real-time, allowing proactive defense mechanisms even for previously unseen ransomware. Together, AAC and TSP offer a comprehensive, layered detection approach that not only improves detection accuracy but also enhances response speed and scalability across diverse network conditions. Through rigorous evaluation, the framework demonstrates significant improvements over traditional methods in detection precision, false-positive reduction, and adaptability to novel ransomware threats, thus showing its potential for integration into advanced cybersecurity infrastructures.