The Inflation Reduction Act (IRA) of 2022 represents a landmark legislative effort aimed at accelerating the United States’ transition to a net-zero emissions economy by 2050. Among its key provisions are incentives designed to bolster the deployment of carbon capture and storage (CCS) technologies. However, the efficacy of these incentives remains uncertain, particularly in scenarios where the cost of CCS remains prohibitively high. This study leverages the Global Change Analysis Model-USA (GCAM-USA) coupled with the Environmental Protection Agency’s Co-Benefits Risk Assessment (COBRA) model to conduct a comprehensive regional assessment of economy-wide technological change, deployment of CO2 removal (CDR) technologies, air quality and public health outcomes by 2050 within the framework of the IRA.